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CCR5 expression influences the progression of human breast cancer in a p53-dependent manner

AutorMañes, Santos; Mira, Emilia; Colomer, Ramón; Montero, Sagrario; Real, Luis M.; Gómez-Moutón, Concepción; Jiménez Baranda, Sonia; Garzón, Alfredo; Lacalle, Rosa Ana; Harshman, Keith; Ruiz, Agustín; Martínez-Alonso, Carlos
Palabras claveChemokine receptor
Breast cancer
p53
CCR5 polymorphism
p38
Fecha de publicaciónnov-2003
EditorRockefeller University Press
CitaciónThe Journal of Experimental Medicine, Volume 198, Number 9, November 3, 2003, pp. 1381–1389
ResumenChemokines are implicated in tumor pathogenesis, although it is unclear whether they affect human cancer progression positively or negatively. We found that activation of the chemokine receptor CCR5 regulates p53 transcriptional activity in breast cancer cells through pertussis toxin–, JAK2-, and p38 mitogen–activated protein kinase–dependent mechanisms. CCR5 blockade significantly enhanced proliferation of xenografts from tumor cells bearing wild-type p53, but did not affect proliferation of tumor xenografts bearing a p53 mutation. In parallel, data obtained in a primary breast cancer clinical series showed that disease-free survival was shorter in individuals bearing the CCR5 32 allele than in CCR5 wild-type patients, but only for those whose tumors expressed wild-type p53. These findings suggest that CCR5 activity influences human breast cancer progression in a p53-dependent manner.
DescripciónCopyright © by The Rockefeller University Press
URIhttp://hdl.handle.net/10261/3299
DOI10.1084/jem.20030580
ISBN0022-1007
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