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dc.contributor.authorCrespo, Helena-
dc.contributor.authorReina, Ramsés-
dc.contributor.authorGlaria, Idoia-
dc.contributor.authorRamírez, Hugo-
dc.contributor.authorAndrés, Ximena de-
dc.contributor.authorJáuregui, Paula-
dc.contributor.authorLuján, Lluís-
dc.contributor.authorMartínez-Pomares, Luisa-
dc.contributor.authorAmorena Zabalza, Beatriz-
dc.contributor.authorAndrés, Damián F. de-
dc.date.accessioned2011-03-02T11:08:07Z-
dc.date.available2011-03-02T11:08:07Z-
dc.date.issued2011-02-07-
dc.identifier.citationVeterinary Research 42: 28-37 (2011)es_ES
dc.identifier.issn0928-4249-
dc.identifier.urihttp://hdl.handle.net/10261/32948-
dc.description10 páginas, 4 figuras, 4 tablas.es_ES
dc.description.abstractThis study aims to characterize the mannose receptor (MR) gene in sheep and its role in ovine visna/maedi virus (VMV) infection. The deduced amino acid sequence of ovine MR was compatible with a transmembrane protein having a cysteine-rich ricin-type amino-terminal region, a fibronectin type II repeat, eight tandem C-type lectin carbohydrate-recognition domains (CRD), a transmembrane region, and a cytoplasmic carboxy-terminal tail. The ovine and bovine MR sequences were closer to each other compared to human or swine MR. Concanavalin A (ConA) inhibited VMV productive infection, which was restored by mannan totally in ovine skin fibroblasts (OSF) and partially in blood monocyte-derived macrophages (BMDM), suggesting the involvement of mannosylated residues of the VMV ENV protein in the process. ConA impaired also syncytium formation in OSF transfected with an ENV-encoding pN3-plasmid. MR transcripts were found in two common SRLV targets, BMDM and synovial membrane (GSM) cells, but not in OSF. Viral infection of BMDM and especially GSM cells was inhibited by mannan, strongly suggesting that in these cells the MR is an important route of infection involving VMV Env mannosylated residues. Thus, at least three patterns of viral entry into SRLV-target cells can be proposed, involving mainly MR in GSM cells (target in SRLV-induced arthritis), MR in addition to an alternative route in BMDM (target in SRLV infections), and an alternative route excluding MR in OSF (target in cell culture). Different routes of SRLV infection may thus coexist related to the involvement of MR differential expression.es_ES
dc.description.sponsorshipThis work was supported by project CICYT Nos. AGL2007-66874-C04-01/GAN and AGL2010-22341-C04-01. We acknowledge the Public University of Navarra and CSIC for fellowships and contract (HC and RR).es_ES
dc.language.isoenges_ES
dc.publisherEDP Scienceses_ES
dc.publisherBioMed Centrales_ES
dc.relation.isversionofPublisher's version-
dc.rightsopenAccesses_ES
dc.titleIdentification of the ovine mannose receptor and its possible role in Visna/Maedi virus infectiones_ES
dc.typeartículoes_ES
dc.identifier.doi10.1186/1297-9716-42-28-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1186/1297-9716-42-28es_ES
dc.rights.licensehttp://creativecommons.org/licenses/by/2.0-
dc.relation.csic-
dc.identifier.pmid21314911-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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