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Multivariate curve resolution: a possible tool in the detection of intermediate structures in protein folding

AuthorsMendieta, Jesús ; Díaz-Cruz, M. Silvia ; Esteban, Miquel; Tauler, Romà
Issue DateJun-1998
PublisherCambridge University Press
CitationBiophysical Journal 74(6): 2876–2888 (1998)
AbstractDifferent multivariate data analysis techniques based on factor analysis and multivariate curve resolution are shown for the study of biochemical evolutionary processes like conformational changes and protein folding. Several simulated CD spectral data sets describing different hypothetical protein folding pathways are analyzed and discussed in relation to the feasibility of factor analysis techniques to detect and resolve the number of components needed to explain the evolution of the CD spectra corresponding to the process (i.e., to detect the presence of intermediate forms). When more than two components (the native and unordered forms) are needed to explain the evolution of the spectra, an iterative multivariate curve resolution procedure based on an alternating least squares algorithm is proposed to estimate the CD spectrum corresponding to the intermediate form.
Description13 pages, 8 figures, 3 tables.-- PMID: 9635741 [PubMed].-- PMCID: PMC1299628.
Publisher version (URL)http://dx.doi.org/10.1016/S0006-3495(98)77994-9
Appears in Collections:(IDAEA) Artículos
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