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dc.contributor.authorTain, Luke S.-
dc.contributor.authorLozano, Encarnación-
dc.contributor.authorSáez, Alberto G.-
dc.contributor.authorLeroi, Armand M.-
dc.identifier.citationBMC Developmental Biology 2008, 8:28en_US
dc.descriptionProvisional abstract and full-text PDF file correspond to the article as it appeared upon acceptance. Fully formatted PDF and final abstract versions will be made available soon.en_US
dc.description.abstract[Background] Dietary restriction (DR) results in increased longevity, reduced fecundity and reduced growth in many organisms. Though many studies have examined the effects of DR on longevity and fecundity, few have investigated the effects on growth.en_US
dc.description.abstract[Results] Here we use Caenorhabditis elegans to determine the mechanisms that regulate growth under DR. We show that rather than a reduction in cell number, decreased growth in wild type C. elegans under DR is correlated with lower levels of hypodermal polyploidization. We also show that mutants lacking wild type sensory ciliated neurons are small, exhibit hypo-polyploidization and more importantly, when grown under DR, reduce their levels of endoreduplication to a lesser extent than wild type, suggesting that these neurons are required for the regulation of hypodermal polyploidization in response to DR. Similarly, we also show that the cGMP-dependent protein kinase EGL-4 and the SMA/MAB signalling pathway regulate polyploidization under DR.en_US
dc.description.abstract[Conclusions] We show C. elegans is capable of actively responding to food levels to regulate adult ploidy. We suggest this response is dependent on the SMA/MAB signalling pathway.en_US
dc.description.sponsorshipOur support came primarily from NERC (UK) and BBSRC. LST was also supported by Parkinson’s Diease Society (PDS). EL and AGS were also supported by programs I3P and Ramón y Cajal, respectively, and by Plan Nacional I+D (CGL2005-00307), all from the Ministry of Education and Science, Spain.en_US
dc.format.extent400557 bytes-
dc.publisherBioMed Centralen_US
dc.relation.isversionofPublisher’s version-
dc.subjectDietary Restrictionen_US
dc.subjectGrowth reductionen_US
dc.subjectCaenorhabditis elegansen_US
dc.subjectHypodermal Polyploidizationen_US
dc.titleDietary regulation of hypodermal polyploidization in C. elegansen_US
dc.description.peerreviewedPeer revieweden_US
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