Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/3259
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Dietary regulation of hypodermal polyploidization in C. elegans |
Autor: | Tain, Luke S.; Lozano, Encarnación CSIC ORCID; Sáez, Alberto G. CSIC ORCID; Leroi, Armand M. | Palabras clave: | Dietary Restriction Growth reduction Caenorhabditis elegans Hypodermal Polyploidization |
Fecha de publicación: | 12-mar-2008 | Editor: | BioMed Central | Citación: | BMC Developmental Biology 2008, 8:28 | Resumen: | [Background] Dietary restriction (DR) results in increased longevity, reduced fecundity and reduced growth in many organisms. Though many studies have examined the effects of DR on longevity and fecundity, few have investigated the effects on growth. [Results] Here we use Caenorhabditis elegans to determine the mechanisms that regulate growth under DR. We show that rather than a reduction in cell number, decreased growth in wild type C. elegans under DR is correlated with lower levels of hypodermal polyploidization. We also show that mutants lacking wild type sensory ciliated neurons are small, exhibit hypo-polyploidization and more importantly, when grown under DR, reduce their levels of endoreduplication to a lesser extent than wild type, suggesting that these neurons are required for the regulation of hypodermal polyploidization in response to DR. Similarly, we also show that the cGMP-dependent protein kinase EGL-4 and the SMA/MAB signalling pathway regulate polyploidization under DR. [Conclusions] We show C. elegans is capable of actively responding to food levels to regulate adult ploidy. We suggest this response is dependent on the SMA/MAB signalling pathway. |
Descripción: | Provisional abstract and full-text PDF file correspond to the article as it appeared upon acceptance. Fully formatted PDF and final abstract versions will be made available soon. | URI: | http://hdl.handle.net/10261/3259 | DOI: | 10.1186/1471-213X-8-28 | ISSN: | 1471-213X |
Aparece en las colecciones: | (MNCN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Dietary_regulation_provisional.pdf | 391,17 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
19
checked on 27-mar-2024
SCOPUSTM
Citations
30
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
28
checked on 24-feb-2024
Page view(s)
362
checked on 23-abr-2024
Download(s)
399
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.