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Título : Graded expression of SNAIL as marker of cancer development and DNA damage-based diseases
Autor : Sánchez García, Isidro; Voces, Felipe; Pérez-Mancera, P. A.
Palabras clave : SNAIL gene
Tumours
Transgenic non-human mammal
SNAIL protein
Cancer
Biological Markers
Fecha de publicación : 1-feb-2007
Citación : International Publication Number: WO 2007/012970 A1
Resumen: The invention relates to the graded expression level of SNAIL gene or its expression products, as a marker of the capacity of epithelial and mesenchymal tumours and/or cancers for disseminating to other tissues or organs. The invention further relates to a transgenic non-human mammal comprising in its genome a transgene that comprises a nucleic acid sequence encoding the SNAIL protein, and the use of SNAIL as a marker of epithelial and mesenchymal tumours and/or cancers as well as in DNA damage-based diseases In addition, the invention relates to the use of SNAIL as a therapeutic and diagnostic target for said pathologies.
Descripción : Filing Date: 2006-07-28.- Priority Data: EP 05076753.2 (2005-07-28).
URI : http://hdl.handle.net/10261/3252
Aparece en las colecciones: (IBMCC) Patentes
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