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Title

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

AuthorsForrester, K.; Almoguera, Concepción CSIC ORCID ; Han, K
KeywordsRNA
Human colon tumour
K-ras genes
Mutations
Oncogenes
Issue Date1987
PublisherNature Publishing Group
CitationNature 327 (6120): 298-303, (1987)
AbstractRNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained.
Publisher version (URL)http://dx.doi.org/10.1038/327298a0
URIhttp://hdl.handle.net/10261/32480
DOIhttp://dx.doi.org/10.1038/327298a0
ISSN0028-0836
E-ISSN1476-4687
Appears in Collections:(IRNAS) Artículos
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