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Title

Epithelial-Mesenchymal Transitions in Development and Disease

AuthorsThiery, Jean Paul; Acloque, Hervé; Huang, Ruby Y. J.; Nieto, M. Ángela CSIC ORCID
Issue Date25-Nov-2009
PublisherElsevier
CitationCell 139(5): 871-890 (2009)
AbstractThe epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Description20 páginas, 7 figuras.
Publisher version (URL)http://dx.doi.org/10.1016/j.cell.2009.11.007
URIhttp://hdl.handle.net/10261/32416
DOI10.1016/j.cell.2009.11.007
ISSN0092-8674
Appears in Collections:(IN) Artículos

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