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Title

Expression of the G protein-coupled receptor kinase 2 during early mouse embryogenesis

AuthorsSefton, Mark; Blanco Fernández de Valderrama, María José; Penela, Petronila ; Mayor Menéndez, Federico ; Nieto, M. Ángela
KeywordsMouse embryo
G protein-coupled receptor kinases
Arrestins
Neural plate
Neural tube
Branchial arches
Neural crest
Heart development
Limb patterning
Mesenchyme
Mesoderm
Migration
Issue Date1-Nov-2000
PublisherElsevier
CitationMechanisms of Development 98(1-2): 127-131 (2000)
AbstractWhilst several G protein-coupled receptors (GPCRs) have been shown to play important roles during development, little study has been carried out on the G protein-coupled receptor kinases (GRKs) that modulate their activity in embryos. Here, we have analyzed the expression of GRK2, the predominant GRK expressed during embryogenesis. We show that at early stages, the expression of GRK2 is restricted to populations of cells that are undifferentiated, multipotent and in many cases, migratory. As such, GRK2 transcripts were found in the early mesoderm and neural crest as they migrate from the primitive streak and the neural tube, respectively. In the limb bud, GRK2 transcripts were observed in cells of the progress zone and in the interdigital areas. At later stages, the expression in the heart is compatible with the phenotype observed in the GRK2 deficient mice.
Description5 páginas, 3 figuras.
Publisher version (URL)http://dx.doi.org/10.1016/S0925-4773(00)00441-X
URIhttp://hdl.handle.net/10261/32316
DOI10.1016/S0925-4773(00)00441-X
ISSN0925-4773
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