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Title

Growth factors as survival factors: Regulation of apoptosis

AuthorsCollins, Mary K. L.; Perkins, Gordon R.; Rodríguez-Tarduchy, Gemma ; Nieto, M. Ángela ; López-Rivas, Abelardo
Issue DateFeb-1994
PublisherWiley-Blackwell
CitationBioessays 16(2): 133-138 (1994)
AbstractApoptosis is now widely recognized as a common form of cell death and represents a mechanism of cell clearance in many physiological situations where deletion of cells is required. Peptide growth factors, initially characterised as stimulators of cell proliferation, have now been shown to inhibit death in many cell types. Deprivation of growth factors leads to the induction of apoptosis, i.e. condensation of chromatin and degradation in oligonucleosomesized fragments, formation of plasma and nuclear membrane blebs and cell fragmentation into apoptotic bodies which can be taken up by neighbouring cells. Here we discuss the mechanism(;s) by which growth factors may inhibit apoptosis.
Description6 páginas, 4 figuras.
Publisher version (URL)http://dx.doi.org/10.1002/bies.950160210
URIhttp://hdl.handle.net/10261/32266
DOI10.1002/bies.950160210
ISSN0265-9247
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