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dc.contributor.author | Casillas-Ramírez, Araní | - |
dc.contributor.author | Zaouali, Mohamed A. | - |
dc.contributor.author | Padrissa-Altés, Susagna | - |
dc.contributor.author | Mosbah, Ismail Ben | - |
dc.contributor.author | Pertosa, Anna | - |
dc.contributor.author | Xaus, Carme | - |
dc.contributor.author | Rodés, Joan | - |
dc.contributor.author | Roselló-Catafau, Joan | - |
dc.contributor.author | Peralta, Carmen | - |
dc.date.accessioned | 2011-01-28T08:25:16Z | - |
dc.date.available | 2011-01-28T08:25:16Z | - |
dc.date.issued | 2009-03-12 | - |
dc.identifier.citation | Endocrinology 150(7): 3153–3161 (2009) | es_ES |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.uri | http://hdl.handle.net/10261/31633 | - |
dc.description.abstract | Hepatic steatosis is a major risk factor in ischemia-reperfusion (I/R). IGF-binding proteins (IGFBPs) modulate IGF-I action by transporting circulating IGF-I to its sites of action. Epidermal growth factor (EGF) stimulates IGF-I synthesis in vitro. We examined the effect of IGF-I and EGF treatment, separately or in combination, on the vulnerability of steatotic livers to I/R. Our results indicated that I/R impaired IGF-I synthesis only in steatotic livers. Only when a high dose of IGF-I (400 _g/kg) was given to obese animals did they show high circulating IGF-I:IGFBP levels, increased hepatic IGF-I levels, and protection against damage. In lean animals, a dose of 100 _g/kg IGF-I protected nonsteatotic livers. Our results indicated that the combined administration of IGF-I and EGF resulted in hepatic injury parameters in both liver types similar to that obtained by IGF-I and EGF separately. IGF-I increased egf expression in both liver types. The beneficial role of EGFonhepatic I/R injurymay be attributable to p38 inhibition in nonsteatotic livers and to PPAR_ overexpression in steatotic livers. In conclusion, IGF-I and EGF may constitute new pharmacological strategies to reduce the inherent susceptibility of steatotic livers to I/R injury. | es_ES |
dc.description.sponsorship | This work was supported by the Ministerio de Educación y Ciencia (Project Grant SAF 2005-00385) (Madrid, Spain), Ministerio de Sanidad y Consumo (Project Grant PIO60021) (Madrid, Spain), and the Generalitat de Catalunya (2005 SGR/00781 Project) (Barcelona, Spain). Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas is funded by the Instituto de Salud Carlos III. | - |
dc.language.iso | eng | es_ES |
dc.publisher | Endocrine Society | es_ES |
dc.rights | openAccess | es_ES |
dc.title | Insulin-like growth factor and epidermal growth factor treatment: new approaches to protecting steatotic livers against ischemia-reperfusion injury | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1210/en.2008-1458 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1210/en.2008-1458 | - |
dc.identifier.e-issn | 1945-7170 | - |
dc.identifier.pmid | 19282385 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Insulin-like growth factor.pdf | 1,45 MB | Adobe PDF | Visualizar/Abrir |
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