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Título: | A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice |
Autor: | Riquelme, Raquel; Cediel, Rafael CSIC; Contreras, Julio CSIC; Rodriguez-de la Rosa, Lourdes CSIC ORCID; Murillo-Cuesta, Silvia CSIC ORCID; Hernández-Sánchez, Catalina ; Zubeldia, José M. CSIC ORCID; Cerdán, Sebastián CSIC ORCID; Varela-Nieto, Isabel CSIC ORCID | Palabras clave: | Aging Auditory brainstem responses Deafness Igf1-/- null mouse Insuline-like factors In vivo brain imaging Presbycusis Sensorineural deafness |
Fecha de publicación: | 13-jul-2010 | Editor: | Frontiers Media | Citación: | Frontiers in Neuroanatomy 4: 27 (2010) | Resumen: | Insulin-like growth factor-I (IGF-I) belongs to the family of insulin-related peptides that fulfils a key role during the late development of the nervous system. Human IGF1 mutations cause profound deafness, poor growth and mental retardation. Accordingly, Igf1(-/-) null mice are dwarfs that have low survival rates, cochlear alterations and severe sensorineural deafness. Presbycusis (age-related hearing loss) is a common disorder associated with aging that causes social and cognitive problems. Aging is also associated with a decrease in circulating IGF-I levels and this reduction has been related to cognitive and brain alterations, although there is no information as yet regarding the relationship between presbycusis and IGF-I biodisponibility. Here we present a longitudinal study of wild type Igf1(+/+) and null Igf1(-/-) mice from 2 to 12 months of age comparing the temporal progression of several parameters: hearing, brain morphology, cochlear cytoarchitecture, insulin-related factors and IGF gene expression and IGF-I serum levels. Complementary invasive and non-invasive techniques were used, including auditory brainstem-evoked response (ABR) recordings and in vivo MRI brain imaging. Igf1(-/-) null mice presented profound deafness at all the ages studied, without any obvious worsening of hearing parameters with aging. Igf1(+/+) wild type mice suffered significant age-related hearing loss, their auditory thresholds and peak I latencies augmenting as they aged, in parallel with a decrease in the circulating levels of IGF-I. Accordingly, there was an age-related spiral ganglion degeneration in wild type mice that was not evident in the Igf1 null mice. However, the Igf1(-/-) null mice in turn developed a prematurely aged stria vascularis reminiscent of the diabetic strial phenotype. Our data indicate that IGF-I is required for the correct development and maintenance of hearing, supporting the idea that IGF-I-based therapies could contribute to prevent or ameliorate age-related hearing loss. | Versión del editor: | http://dx.doi.org/10.3389/fnana.2010.00027 | URI: | http://hdl.handle.net/10261/31549 | DOI: | 10.3389/fnana.2010.00027 | ISSN: | 1662-5129 |
Aparece en las colecciones: | (IIBM) Artículos (CIB) Artículos |
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Frontiers in neuroanatomy 2010 vol4 art27 pp1.pdf | 2,98 MB | Adobe PDF | Visualizar/Abrir |
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