Maternal high fat diets based on olive oil protect offspring against nafld features through epigenetic alterations

Abstract

Dietary fatty acids intake and their composition play a role in nonalcoholic fatty liver disease (NAFLD) pathogenesis, being the main hepatic manifestation of metabolic syndrome. Maternal obesogenic diet exposure contributes to offspring's NAFLD susceptibility. We examined if a maternal high fat diet (HFD) based on extra virgin olive oil (EVOO), rich in monounsaturated fatty acids and poliphenols, reduces the risk of offspring NAFLD through epigenetic microRNA (miR) changes.