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Título

Convergence of the TOR and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional activator of STRE regulated genes

Autor Mayordomo, Isabel; Estruch, Francisco; Sanz, Pascual
Palabras clave protein kinase pathways
Stress regulated genes
Fecha de publicación sep-2002
EditorAmerican Society for Biochemistry and Molecular Biology
Citación Journal of Biological Chemistry 277(38) : 35650-35656 (2002)
ResumenThe subcellular localization of Msn2, a transcriptional activator of STRE (Stress Response Element) regulated genes, is modulated by carbon source availability. In cells growing in glucose, Msn2 is located mainly in the cytosol, whereas in carbon source-starved cells, Msn2 is located largely inside the nucleus. However, in cells lacking Reg1 (the regulatory subunit of the Reg1/Glc7 protein phosphatase complex), the regulation of subcellular distribution is absent, Msn2 being constitutively present in the cytosol. The localization defect in these mutants is specific for carbon starvation stress and it is due to the presence of an abnormally active Snf1 protein kinase that inhibits the nuclear localization of Msn2 upon carbon starvation. Active Snf1 kinase is also able to avoid the effects of rapamycin, a drug that by inhibiting the TOR kinase pathway leads to a nuclear localization of Msn2 in wild type cells. Therefore, active Snf1 and the TOR kinase pathway may affect similar cytosolic steps in the regulation of the subcellular localization of Msn2.
URI http://hdl.handle.net/10261/3075
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