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Título: | MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages |
Autor: | Raue, Rebecca; Frank, Ann-Christin; Fuhrmann, Dominik C.; Cruz, Patricia de la CSIC; Rösser, Silvia; Bauer, Rebekka; Cardamone, Giulia; Weigert, Andreas; Syed, Shahzad Nawaz; Schmid, Tobias; Brüne, Bernhard | Palabras clave: | Breast tumor Macrophage miR Tumor microenvironment |
Fecha de publicación: | mar-2022 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Biology 11(3): 349 (2022) | Resumen: | Macrophages constitute a major part of the tumor-infiltrating immune cells. Within the tumor microenvironment, they acquire an alternatively activated, tumor-supporting phenotype. Factors released by tumor cells are crucial for the recruitment of tumor-associated macrophages. In the present project, we aimed to understand the role of hsa-miR-200c-3p (miR-200c) in the interplay between tumor cells and macrophages. To this end, we employed a coculture system of MCF7 breast tumor cells and primary human macrophages and observed the transfer of miR-200c from apoptotic tumor cells to macrophages, which required intact CD36 receptor in macrophages. We further comprehensively determined miR-200c targets in macrophages by mRNA-sequencing and identified numerous migration-associated mRNAs to be downregulated by miR-200c. Consequently, miR-200c attenuated macrophage infiltration into 3-dimensional tumor spheroids. miR-200c-mediated reduction in infiltration further correlated with a miR-200c migration signature comprised of the four miR-200c-repressed, predicted targets PPM1F, RAB11FIB2, RDX, and MSN. | Versión del editor: | https://doi.org/10.3390/biology11030349 | URI: | http://hdl.handle.net/10261/306755 | DOI: | 10.3390/biology11030349 | E-ISSN: | 2079-7737 |
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MicroRNA_200c_Raue.pdf | 5,97 MB | Adobe PDF | Visualizar/Abrir |
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