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Título

MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages

AutorRaue, Rebecca; Frank, Ann-Christin; Fuhrmann, Dominik C.; Cruz, Patricia de la CSIC; Rösser, Silvia; Bauer, Rebekka; Cardamone, Giulia; Weigert, Andreas; Syed, Shahzad Nawaz; Schmid, Tobias; Brüne, Bernhard
Palabras claveBreast tumor
Macrophage
miR
Tumor microenvironment
Fecha de publicaciónmar-2022
EditorMultidisciplinary Digital Publishing Institute
CitaciónBiology 11(3): 349 (2022)
ResumenMacrophages constitute a major part of the tumor-infiltrating immune cells. Within the tumor microenvironment, they acquire an alternatively activated, tumor-supporting phenotype. Factors released by tumor cells are crucial for the recruitment of tumor-associated macrophages. In the present project, we aimed to understand the role of hsa-miR-200c-3p (miR-200c) in the interplay between tumor cells and macrophages. To this end, we employed a coculture system of MCF7 breast tumor cells and primary human macrophages and observed the transfer of miR-200c from apoptotic tumor cells to macrophages, which required intact CD36 receptor in macrophages. We further comprehensively determined miR-200c targets in macrophages by mRNA-sequencing and identified numerous migration-associated mRNAs to be downregulated by miR-200c. Consequently, miR-200c attenuated macrophage infiltration into 3-dimensional tumor spheroids. miR-200c-mediated reduction in infiltration further correlated with a miR-200c migration signature comprised of the four miR-200c-repressed, predicted targets PPM1F, RAB11FIB2, RDX, and MSN.
Versión del editorhttps://doi.org/10.3390/biology11030349
URIhttp://hdl.handle.net/10261/306755
DOI10.3390/biology11030349
E-ISSN2079-7737
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