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Título: | Constipation Predicts Cognitive Decline in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-up and Comparison with a Control Group |
Autor: | Santos-García, Diego; García Roca, Lucía; Deus Fonticoba, T. de; Cores Bartolomé, Carlos; Naya Ríos, Lucía; Canfield, Hector; Paz González, J. M.; Martínez Miró, Cristina; Jesús Maestre, Silvia CSIC ORCID; Aguilar Barberá, Miquel; Pastor, Pau; Planellas, Lluís; Cosgaya, Marina; García Caldentey, Juan; Caballol, Nuria; Legarda, Inés; Hernández-Vara, Jorge; Cabo, Iria; López-Manzanares, Lydia; González-Aramburu, Isabel; Ávila-Rivera, María A.; Gómez Mayordomo, Víctor; Nogueira, Víctor; Puente, Víctor; Dotor, Julio; Borrué, Carmen; Solano Vila, Berta; Álvarez-Sauco, María; Vela, Lydia; Escalante, Sonia; Cubo, Esther; Carrillo Padilla, Francisco; Martínez-Castrillo, J. C.; Sánchez Alonso, Pilar; Alonso Losada, María G.; López-Ariztegui, Nuria; Gastón, Itziar; Kulisevsky, Jaime; Blázquez-Estrada, Marta; Seijo, Manuel; Ruiz Martínez, Javier; Valero, Caridad; Kurtis, Mónica; Fábregues-Boixar, Oriol de; González Ardura, Jessica; Alonso Redondo, Rubén; Ordás, Carlos; López-Díaz, Luis M.; McAfee, Darrian; Martínez-Martín, Pablo; Mir, Pablo CSIC ORCID | Palabras clave: | Cognition Parkinson’s disease Constipation Impairment Non-motor symptoms |
Fecha de publicación: | 21-ene-2022 | Editor: | IOS Press | Citación: | Journal of Parkinson's Disease 12(1): 315-331 (2022) | Resumen: | [Background] Constipation has been linked to cognitive impairment development in Parkinson’s disease (PD). Objective:Our aim was to analyze cognitive changes observed in PD patients and controls from a Spanish cohort with regards to the presence or not of constipation. Methods:PD patients and controls recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017 were followed-up during 2 years. The change in cognitive status from baseline (V0) to 2-year follow-up was assessed with the PD-CRS (Parkinson’s Disease Cognitive Rating Scale). Subjects with a score ≥1 on item 21 of the NMSS (Non-Motor Symptoms Scale) at baseline (V0) were considered as “with constipation”. Regression analyses were applied for determining the contribution of constipation in cognitive changes. [Results] At V0, 39.7% (198/499) of PD patients presented constipation compared to 11.4% of controls (14/123) (p < 0.0001). No change was observed in cognitive status (PD-CRS total score) neither in controls without constipation (from 100.24±13.72 to 100.27±13.68; p = 0.971) and with constipation (from 94.71±10.96 to 93.93±13.03; p = 0.615). The PD-CRS total score decreased significantly in PD patients with constipation (from 89.14±15.36 to 85.97±18.09; p < 0.0001; Coehn’s effect = –0.35) compared to patients without constipation (from 93.92±15.58 to 93.14±17.52; p = 0.250) (p = 0.018). In PD patients, to suffer from constipation at V0 was associated with a decrease in the PD-CRS total score from V0 to V2 (β= –0.1; 95% CI, –4.36 – –0.27; p = 0.026) and having cognitive impairment at V2 (OR = 1.79; 95% CI, 1.01 – 3.17; p = 0.045). Conclusion:Constipation is associated with cognitive decline in PD patients but not in controls. [Conclusion] Constipation is associated with cognitive decline in PD patients but not in controls. |
Versión del editor: | https://doi.org/10.3233/JPD-212868 | URI: | http://hdl.handle.net/10261/305139 | DOI: | 10.3233/JPD-212868 | ISSN: | 1877-7171 | E-ISSN: | 1877-718X |
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