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Título: | Fabrication and assessment of bifunctional electrospun poly(L-lactic acid) scaffolds with bioglass and zinc oxide nanoparticles for bone tissue engineering |
Autor: | Canales, D. A.; Piñones, N.; Saavedra, M.; Loyo, C.; Palza, H.; Peponi, Laura CSIC ORCID; Leonés, Adrián CSIC ORCID; Baier, R.V.; Boccaccini, Aldo R.; Grünewald, A.; Zapata, Paula A. | Palabras clave: | Bone tissue engineering Electrospun fibers Poly(lactic acid) based nanocomposites Bioglass nanoparticle Zinc oxide nanoparticle Functional scaffolds | Fecha de publicación: | 2023 | Editor: | Elsevier BV | Citación: | International Journal of Biological Macromolecules 228: 78- 88 (2023) | Resumen: | Electrospun scaffolds based on poly(L-lactic acid) (PLLA) with bioglass (n-BG) and zinc oxide (n-ZnO), and mixture of both, were developed to design bifunctional biomaterials with enhanced bioactive and biocidal properties. The presence of n-BG increased the fiber diameter of the pure PLA from 1.5 ± 0.3 μm to 3.0 ± 0.8 μm for 20 wt%. ZnO and the mixed nanoparticles did not significantly affect the morphology. The mechanical properties decreased with the presence of nanoparticles. Scaffolds based on PLA/n-BG promoted hydroxyapatite (HA) formation in simulated body fluid (SBF) that was inhibited with the presence of ZnO. Notably, mixed particles produced bioactivity although at longer times. The incorporation of n-ZnO produced a biocidal capacity against S. aureus in the polymeric scaffold, reaching a viability reduction of 60 % after 6 h of exposure. When both types of nanoparticles were combined, the bacterial viability reduction was 30 %. Pure PLA scaffolds and the composites with n-BG showed good ST-2 bone marrow-derived cell line viability, scaffolds with n-BG (pure or mixture) presented lower viability. Results validated the use of both n-BG and n-ZnO fillers for the development of novel bifunctional PLA-based scaffolds with both bioactive and biocidal properties for bone tissue engineering applications. | Versión del editor: | http://dx.doi.org/10.1016/j.ijbiomac.2022.12.195 | URI: | http://hdl.handle.net/10261/303846 | DOI: | 10.1016/j.ijbiomac.2022.12.195 | Identificadores: | doi: 10.1016/j.ijbiomac.2022.12.195 issn: 1879-0003 |
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