English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/2928
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
 |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Expression of Canonical SOS Genes Is Not under LexA Repression in Bdellovibrio bacteriovorus
Autor : Campoy, Susana; Salvador, Noelia; Cortés, Pilar; Erill, Iván; Barbé, Jordi
Fecha de publicación : ago-2005
Editor: American Society for Microbiology
Citación : J Bacteriol. 2005 August; 187(15): 5367–5375.
http://dx.doi.org/10.1128/JB.187.15.5367–5375.2005
Resumen: The here-reported identification of the LexA-binding sequence of Bdellovibrio bacteriovorus, a bacterial predator belonging to the δ-Proteobacteria, has made possible a detailed study of its LexA regulatory network. Surprisingly, only the lexA gene and a multiple gene cassette including dinP and dnaE homologues are regulated by the LexA protein in this bacterium. In vivo expression analyses have confirmed that this gene cassette indeed forms a polycistronic unit that, like the lexA gene, is DNA damage inducible in B. bacteriovorus. Conversely, genes such as recA, uvrA, ruvCAB, and ssb, which constitute the canonical core of the Proteobacteria SOS system, are not repressed by the LexA protein in this organism, hinting at a persistent selective pressure to maintain both the lexA gene and its regulation on the reported multiple gene cassette. In turn, in vitro experiments show that the B. bacteriovorus LexA-binding sequence is not recognized by other δ-Proteobacteria LexA proteins but binds to the cyanobacterial LexA repressor. This places B. bacteriovorus LexA at the base of the δ-Proteobacteria LexA family, revealing a high degree of conservation in the LexA regulatory sequence prior to the diversification and specialization seen in deeper groups of the Proteobacteria phylum.
URI : http://hdl.handle.net/10261/2928
DOI: 10.1128/JB.187.15.5367–5375.2005
ISSN: 0021-9193
Aparece en las colecciones: (IMB-CNM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Bdellovibrio.pdf279,2 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.