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Título: | Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus |
Autor: | Gómez, Nuria; Wigdorovitz, A.; Castañón, S.; Gil, Félix; Ordá, R.; Borca, M. V.; Escribano, J. M. | Fecha de publicación: | 2000 | Editor: | Springer Nature | Citación: | Archives of Virology 145: 1725-1732 (2000) | Resumen: | Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from Transmissible gastroenteritis coronavirus (TGEV), containing the major antigenic sites of the protein. Extracts from potato tubers expressing N-gS were inoculated intraperitoneally to mice, and the vaccinated mice developed serum IgG specific for TGEV. Furthermore, when potato tubers expressing N-gS were fed directly to mice, they developed serum antibodies specific for gS protein, demonstrating the oral immunogenicity of the plant derived spike protein from TGEV. | URI: | http://hdl.handle.net/10261/292366 | DOI: | 10.1007/s007050070087 | ISSN: | 0304-8608 | E-ISSN: | 1432-8798 |
Aparece en las colecciones: | (INIA) Artículos (PTI Salud Global) Colección Especial COVID-19 |
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