English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/29194
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Phosphorylated peptides can be transported by TAP molecules, presented by class I MHC molecules, and recognized by phosphopeptide-specific CTL

AuthorsAndersen, Mads Hald; Bonfil, Jordi Espuny; Neisig, Anne; Arsequell, Gemma ; Søndergaard, Ib; Neefjes, Jacques; Zeuthen, Jesper; Elliott, Tim; Haurum, John S.
Issue DateOct-1999
PublisherAmerican Association of Immunologists
CitationJournal of Immunology 163(7):3812-8 (1999)
AbstractCTL recognize short peptide fragments presented by class I MHC molecules. In this study, we examined the effect of phosphorylation on TAP transport, binding to class I MHC molecules, and recognition by CTL of peptide fragments from known phosphorylated oncogene proteins or virus phosphoproteins. We show that phosphopeptides can be efficiently transported from the cytosol to the endoplasmic reticulum by the TAP. Furthermore, we show that phosphorylation can have a neutral, negative, or even a positive effect on peptide binding to class I MHC. Finally, we have generated phosphopeptide-specific CTL that discriminate between the phosphorylated and the nonphosphorylated versions of the peptide. We conclude that phosphopeptide-specific CTL responses are likely to constitute a subset of the class I MHC-restricted CTL repertoire in vivo.
Description8 pages, 4 figures, 2 tables.-- PMID: 10490979 [PubMed].
Publisher version (URL)http://www.jimmunol.org/cgi/reprint/163/7/3812
URIhttp://hdl.handle.net/10261/29194
ISSN0022-1767
E-ISSN1550-6606
Appears in Collections:(IQAC) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.