Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/291772
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | A new single nucleotide polymorphism in the calpastatin (CAST) gene associated with beef tenderness |
Autor: | Calvo, Jorge Hugo; Iguácel, Laura Pilar; Kirinus, J. K.; Serrano Noreña, Magdalena CSIC ORCID; Ripoll, G.; Casasús, I.; Joy, M.; Pérez-Velasco, L.; Sarto, María Pilar; Albertí, P.; Blanco, M. | Palabras clave: | Tenderness Cattle CAST CAPN1 SNP |
Fecha de publicación: | 2014 | Editor: | Elsevier | Citación: | Meat Science 96(2): 775-782 (2014) | Resumen: | First we looked for putative causative mutations in the CAST and CAPN1 genes associated with meat tenderness and found a total of 31 and 7 polymorphisms, respectively, in the Parda de Montaña and Pirenaica breeds. Tenderness was not affected by mutations in CAPN1. However, three SNPs located at intron 5 (BTA7 g.98533962C>G on UMD 3.0), exon 7 (g.98535683A>G) and intron 12 (g.98545188T>A) of the CAST gene were significantly associated with meat tenderness at 7days post-mortem in the Parda de Montaña breed. The haplotypes h2 and h5 showed significant associations with meat toughness being consistent with the SNP association results, which showed that the g.98535683A>G SNP in CAST might be the causative mutation of the effect found in this study. This mutation changes the amino acid sequence at position p.Thr182Ala (NM_174003). This amino acid substitution could affect the interacting regions between the calpastatin L-domain and calpain, and then could generate a more stable union between calpain and calpastatin. © 2013 Elsevier Ltd. | URI: | http://hdl.handle.net/10261/291772 | DOI: | 10.1016/j.meatsci.2013.10.003 | ISSN: | 0309-1740 |
Aparece en las colecciones: | (INIA) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
32
checked on 20-abr-2024
WEB OF SCIENCETM
Citations
31
checked on 26-feb-2024
Page view(s)
16
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.