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| Título: | A new non-aggregative splicing isoform of human tau is decreased in Alzheimer's disease |
Otros títulos: | Neue nichtaggregative spleiss-isoform von humanem tau wird bei morbus Alzheimer verringert Nouvel isoforme d'épissage non aggrégatif de tau humain réduite dans la maladie d'Alzheimer |
Autor: | Ávila, Jesús CSIC ORCID ; Lucas, José Javier CSIC ORCID; Cuadros, Raquel CSIC ; García, Esther; García-Escudero, Vega CSIC ORCID CVN; Hernández Pérez, Félix CSIC ORCID; Ruiz-Gabarre, Daniel | Fecha de publicación: | 12-oct-2022 | Citación: | EP4071165 A1 | Resumen: | The present invention refers to a composition of matter comprising at least one peptide inhibitor (from hereinafter "peptide inhibitor/s of the invention") that reduces or prevents amyloid beta (Ab) and/or tau aggregation and toxicity, preferably of already-aggregated species, wherein the at least one peptide inhibitor comprises or consists of an amino acid sequence WVGCCPW (SEQ ID NO 1), KKVKGVGWVGCCPWVYGH (SEQ ID NO 2), GVGWVG (SEQ ID NO 3), GWVGCCPW (SEQ ID NO 4), VGWVGCCPW (SEQ ID NO 5), GVGWVGCCPW (SEQ ID NO 6), KGVGWVGCCPW (SEQ ID NO 7), VKGVGWVGCCPW (SEQ ID NO 8), WVGCCPWV (SEQ ID NO 9), GWVGCCPWV (SEQ ID NO 10), WVGCCPWVY (SEQ ID NO 11), WVGCCPWVYG (SEQ ID NO 12) or WVGCCPWVYGH (SEQ ID NO: 13) or any combination thereof. | URI: | http://hdl.handle.net/10261/288798 |
| Aparece en las colecciones: | (CBM) Patentes |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| EP4071165A1_Alzheimer.pdf | 19,29 MB | Adobe PDF |  Visualizar/Abrir |
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