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Título: | Acute and chronic MRI changes in the spine and spinal cord after surgical stem cell grafting in patients with definite amyotrophic lateral sclerosis: Post-infusion injuries are unrelated with clinical impairment |
Autor: | García Santos, José M.; Blanquer, Miguel; Torres del Río, Silvia; Iniesta, Francisca; Gómez Espuch, Joaquín; Pérez-Espejo, Miguel Ángel; Martínez, Salvador CSIC ORCID; Moraleda, José María | Fecha de publicación: | 2013 | Editor: | Elsevier | Citación: | Magnetic Resonance Imaging 31(8): 1298-1308 (2013) | Resumen: | [Objective] To report MRI spinal changes after surgical infusion of bone marrow stem cells (BMSc) in ALS patients and assess their correlation with clinical events and functional performance. [Methods] BMSc were surgically injected in the thoracic spinal cord of 11 ALS patients (6/5 male/female; median age 46 years). We performed first-week and third, sixth, ninth and twelfth post-surgical months spinal MRIs. The spinal changes in the postsurgical week and follow-up MRIs, as well as clinical events, functional scales and respiratory and electromyography data, were longitudinally monitored. Correlations between the imaging and clinical data were evaluated with the Spearman's test. [Results] Transient extradural fluid collections (100%), transient spinal cord T2 hyperintensity (81.8%), and chronic spinal cord deformities (63.6%) were the dominating MRI changes. Spinal cord hemorrhages (27.3%) and cystic myelomalacia (1/11 patients) were important although unusual findings. During the follow-up, minor adverse events of mild to moderate intensity eventually improved. Initial and follow-up imaging scores showed a strongly positive correlation (r 0.879, P < 0.001). The initial and delayed clinical scores did not correlate. There was no significant correlation between any of the imaging scores and clinical data. [Conclusions] Infusion of BMSc produces a variety of spinal changes apparently unrelated with clinical events and disease worsening. |
Versión del editor: | https://doi.org/10.1016/j.mri.2013.05.006 | URI: | http://hdl.handle.net/10261/288409 | DOI: | 10.1016/j.mri.2013.05.006 | ISSN: | 0730-725X |
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