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Título

Correction to: A 2-Step Strategy Combining FIB-4 With Transient Elastography and Ultrasound Predicted Liver Cancer After HCV Cure

AutorAmpuero, Javier CSIC ORCID; Carmona Soria, Isabel; Sousa, Francisca; Rosales, José Miguel; López-Garrido, Ángeles; Casado, Marta CSIC ORCID ; Figueruela, Blanca; Aparicio-Serrano, Ana; Andrade, Raúl J.; Guerra Veloz, M. F.; Maraver, Marta; Pascasio, Juan Manuel CSIC; Estévez, Matías; Romero-Gómez, Manuel CSIC ORCID CVN
Fecha de publicaciónmay-2022
EditorLippincott Williams & Wilkins
CitaciónAmerican Journal of Gastroenterology 117(5): 819 (2022)
Resumen[Introduction] Despite the direct-acting antiviral therapy has dramatically decreased the likelihood of having liver-related complications and extrahepatic outcomes, the risk of developing hepatocellular carcinoma (HCC) is not totally eliminated after sustained virological response (SVR). We aimed to develop an easy-to-apply strategy to be adopted in clinical practice for accurately classifying the HCC risk in hepatitis C virus patients after SVR.
[Methods] Prospective and multicenter study enrolling hepatitis C virus patients with advanced fibrosis (transient elastography [TE] > 10 kPa) or cirrhosis by ultrasound showing SVR. They were followed up until HCC, liver transplantation, death, or until October 2020, which occurred first, with a minimum follow-up period of 6 months after SVR (follow-up: 49 [interquartile range 28–59] months).
[Results] Patients with cirrhosis by ultrasound represented 58% (611/1,054) of the overall cohort. During the study, HCC occurrence was 5.3% (56/1,054). Multivariate analyses revealed that Fibrosis-4 (FIB-4) > 3.25 (hazard ratio [HR] 2.26 [1.08–4.73]; P = 0.030), TE (HR 1.02 [1.00–1.04]; P = 0.045) and cirrhosis by ultrasound (HR 3.15 [1.36–7.27]; P = 0.007) predicted HCC occurrence. Baseline HCC screening criteria (TE > 10 kPa or cirrhosis) identified patients at higher risk of HCC occurrence in presence of FIB-4 > 3.25 (8.8%; 44/498) vs FIB-4 < 3.25 (2.4%; 12/506), while those with only FIB > 3.25 had no HCC (0%; 0/50) (logRank 22.129; P = 0.0001). A combination of baseline FIB-4 > 3.25 and HCC screening criteria had an annual incidence >1.5 cases per 100 person-years, while the rest of the groups remained <1 case. Patients who maintained post-treatment FIB-4 > 3.25 and HCC screening criteria remained at the highest risk of HCC occurrence (13.7% [21/153] vs 4.9% [9/184]; logRank 7.396, P = 0.007).
[Discussion] We demonstrated that a two-step strategy combining FIB-4, TE, and ultrasound could help stratify HCC incidence risk after SVR.
DescripciónIn the January 2022 issue of The American Journal of Gastroenteroloy, one of the authors was misidentified. The author's correct full name is Ana Aparicio-Serrano.
Versión del editorhttps://dx.doi.org/10.14309/ajg.0000000000001705
URIhttp://hdl.handle.net/10261/288053
DOI10.14309/ajg.0000000000001705
ISSN0002-9270
1572-0241
ReferenciasAmpuero, Javier; Carmona Soria, Isabel; Sousa, Francisca; Rosales, Jose Miguel; López-Garrido, Ángeles; Casado, Marta; Figueruela, Blanca; Aparicio-Serrano, Ana; Andrade, Raúl J.; Guerra Veloz, M. F.; Maraver, Marta; Pascasio, Juan Manuel CSIC; Estévez, Matías; Romero-Gómez, Manuel. A 2-Step Strategy Combining FIB-4 With Transient Elastography and Ultrasound Predicted Liver Cancer After HCV Cure. American Journal of Gastroenterology 117(1): 138-146 (2022). https://doi.org/10.14309/ajg.0000000000001503 . http://hdl.handle.net/10261/288050
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