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Título: | Correction to: A 2-Step Strategy Combining FIB-4 With Transient Elastography and Ultrasound Predicted Liver Cancer After HCV Cure |
Autor: | Ampuero, Javier CSIC ORCID; Carmona Soria, Isabel; Sousa, Francisca; Rosales, José Miguel; López-Garrido, Ángeles; Casado, Marta CSIC ORCID ; Figueruela, Blanca; Aparicio-Serrano, Ana; Andrade, Raúl J.; Guerra Veloz, M. F.; Maraver, Marta; Pascasio, Juan Manuel CSIC; Estévez, Matías; Romero-Gómez, Manuel CSIC ORCID CVN | Fecha de publicación: | may-2022 | Editor: | Lippincott Williams & Wilkins | Citación: | American Journal of Gastroenterology 117(5): 819 (2022) | Resumen: | [Introduction] Despite the direct-acting antiviral therapy has dramatically decreased the likelihood of having liver-related complications and extrahepatic outcomes, the risk of developing hepatocellular carcinoma (HCC) is not totally eliminated after sustained virological response (SVR). We aimed to develop an easy-to-apply strategy to be adopted in clinical practice for accurately classifying the HCC risk in hepatitis C virus patients after SVR. [Methods] Prospective and multicenter study enrolling hepatitis C virus patients with advanced fibrosis (transient elastography [TE] > 10 kPa) or cirrhosis by ultrasound showing SVR. They were followed up until HCC, liver transplantation, death, or until October 2020, which occurred first, with a minimum follow-up period of 6 months after SVR (follow-up: 49 [interquartile range 28–59] months). [Results] Patients with cirrhosis by ultrasound represented 58% (611/1,054) of the overall cohort. During the study, HCC occurrence was 5.3% (56/1,054). Multivariate analyses revealed that Fibrosis-4 (FIB-4) > 3.25 (hazard ratio [HR] 2.26 [1.08–4.73]; P = 0.030), TE (HR 1.02 [1.00–1.04]; P = 0.045) and cirrhosis by ultrasound (HR 3.15 [1.36–7.27]; P = 0.007) predicted HCC occurrence. Baseline HCC screening criteria (TE > 10 kPa or cirrhosis) identified patients at higher risk of HCC occurrence in presence of FIB-4 > 3.25 (8.8%; 44/498) vs FIB-4 < 3.25 (2.4%; 12/506), while those with only FIB > 3.25 had no HCC (0%; 0/50) (logRank 22.129; P = 0.0001). A combination of baseline FIB-4 > 3.25 and HCC screening criteria had an annual incidence >1.5 cases per 100 person-years, while the rest of the groups remained <1 case. Patients who maintained post-treatment FIB-4 > 3.25 and HCC screening criteria remained at the highest risk of HCC occurrence (13.7% [21/153] vs 4.9% [9/184]; logRank 7.396, P = 0.007). [Discussion] We demonstrated that a two-step strategy combining FIB-4, TE, and ultrasound could help stratify HCC incidence risk after SVR. |
Descripción: | In the January 2022 issue of The American Journal of Gastroenteroloy, one of the authors was misidentified. The author's correct full name is Ana Aparicio-Serrano. | Versión del editor: | https://dx.doi.org/10.14309/ajg.0000000000001705 | URI: | http://hdl.handle.net/10261/288053 | DOI: | 10.14309/ajg.0000000000001705 | ISSN: | 0002-9270 1572-0241 |
Referencias: | Ampuero, Javier; Carmona Soria, Isabel; Sousa, Francisca; Rosales, Jose Miguel; López-Garrido, Ángeles; Casado, Marta; Figueruela, Blanca; Aparicio-Serrano, Ana; Andrade, Raúl J.; Guerra Veloz, M. F.; Maraver, Marta; Pascasio, Juan Manuel CSIC; Estévez, Matías; Romero-Gómez, Manuel. A 2-Step Strategy Combining FIB-4 With Transient Elastography and Ultrasound Predicted Liver Cancer After HCV Cure. American Journal of Gastroenterology 117(1): 138-146 (2022). https://doi.org/10.14309/ajg.0000000000001503 . http://hdl.handle.net/10261/288050 |
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