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Title

Pneumococcal LytA Autolysin, a Potent Therapeutic Agent in Experimental Peritonitis-Sepsis Caused by Highly β-Lactam-Resistant Streptococcus pneumoniae

AuthorsSoriano, Francisco; Rodríguez-Cerrato, Violeta; García, Pedro CSIC ORCID ; Huelves, Lorena; García, Ernesto CSIC ORCID ; Prado, Gema del; Gracia, Matilde; Ponte, Carmen; López, Rubens
Issue Date18-Jun-2007
PublisherAmerican Society for Microbiology
CitationAntimicrob Agents Chemother. 2007 September; 51(9): 3371–3373
PMCID: 2043201
AbstractThe in vitro and in vivo antipneumococcal activities of the main pneumococcal autolysin (LytA) and Cpl-1, a lysozyme encoded by phage Cp-1, were studied. Intraperitoneal therapy with LytA or high-dose Cpl-1 remarkably reduced peritoneal bacterial counts (>5 log10 CFU/ml) compared with those for the controls. After intravenous injection, LytA was the most effective treatment.
URIhttp://hdl.handle.net/10261/2875
DOI10.1128/AAC.00137-07
ISSN0066-4804
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