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Título: | Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments |
Autor: | Fernández-Villa, Daniel CSIC ORCID; Ramírez-Jiménez, Rosa Ana CSIC ORCID ; Aranaz, Inmaculada CSIC ORCID; Acosta, Niuris; Vázquez-Lasa, Blanca CSIC ORCID; Rojo, Luis CSIC ORCID | Palabras clave: | methotrexate strontium zinc magnesium glycosaminoglycans nitric oxide antiinflammatory properties chitosan microparticles |
Fecha de publicación: | 2022 | Editor: | Molecular Diversity Preservation International | Citación: | International Journal of Molecular Sciences 23 (2022) | Resumen: | Methotrexate (MTX) administration is the gold standard treatment for rheumatoid arthritis (RA), but its effects are limited to preventing the progression of the disease. Therefore, effective regenerative therapies for damaged tissues are still to be developed. In this regard, MTX complexes of general molecular formula M(MTX)·xHO, where M = Sr, Zn, or Mg, were synthesized and physicochemically characterized by TGA, XRD, NMR, ATR–FTIR, and EDAX spectroscopies. Characterization results demonstrated the coordination between the different cations and MTX via two monodentate bonds with the carboxylate groups of MTX. Cation complexation provided MTX with new bioactive properties such as increasing the deposition of glycosaminoglycans (GAGs) and alternative anti-inflammatory capacities, without compromising the immunosuppressant properties of MTX on macrophages. Lastly, these new complexes were loaded into spray-dried chitosan microparticles as a proof of concept that they can be encapsulated and further delivered in situ in RA-affected joints, envisioning them as a suitable alternative to oral MTX therapy. | Versión del editor: | http://dx.doi.org/10.3390/ijms231710054 | URI: | http://hdl.handle.net/10261/284912 | DOI: | 10.3390/ijms231710054 | Identificadores: | doi: 10.3390/ijms231710054 issn: 1422-0067 |
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