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Título: | Primary Cilia in Pancreatic ß- and ¿-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme |
Autor: | Pablos, Marta; Casanueva-Álvarez, Elena CSIC ORCID; González-Casimiro, Carlos M. CSIC ORCID; Merino, Beatriz CSIC ORCID CVN; Perdomo, Germán CSIC ORCID CVN; Cózar-Castellano, Irene CSIC ORCID CVN | Palabras clave: | Primary cilium Insulin-degrading enzyme Pancreas β-cell α-cell Insulin signaling Insulin Proliferation |
Fecha de publicación: | 2022 | Editor: | Frontiers Media | Citación: | Frontiers in Endocrinology 13: 922825 (2022) | Resumen: | The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signaling molecules are highly or differentially expressed in primary cilium. Rare genetic disorders that affect cilia integrity and function, such as Bardet-Biedl syndrome and Alström syndrome, have awoken interest in studying the biology of cilium. In this review, we discuss recent evidence suggesting emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic β- and α-cell functions, and its implications in regulating glucose homeostasis | Versión del editor: | http://dx.doi.org/10.3389/fendo.2022.922825 | URI: | http://hdl.handle.net/10261/282468 | DOI: | 10.3389/fendo.2022.922825 | Identificadores: | doi: 10.3389/fendo.2022.922825 e-issn: 1664-2392 |
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Primary Cilia_Pablos_Art2022.pdf | 4,04 MB | Adobe PDF | Visualizar/Abrir |
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