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Título

Primary Cilia in Pancreatic ß- and ¿-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme

AutorPablos, Marta; Casanueva-Álvarez, Elena CSIC ORCID; González-Casimiro, Carlos M. CSIC ORCID; Merino, Beatriz CSIC ORCID CVN; Perdomo, Germán CSIC ORCID CVN; Cózar-Castellano, Irene CSIC ORCID CVN
Palabras clavePrimary cilium
Insulin-degrading enzyme
Pancreas
β-cell
α-cell
Insulin signaling
Insulin
Proliferation
Fecha de publicación2022
EditorFrontiers Media
CitaciónFrontiers in Endocrinology 13: 922825 (2022)
ResumenThe primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signaling molecules are highly or differentially expressed in primary cilium. Rare genetic disorders that affect cilia integrity and function, such as Bardet-Biedl syndrome and Alström syndrome, have awoken interest in studying the biology of cilium. In this review, we discuss recent evidence suggesting emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic β- and α-cell functions, and its implications in regulating glucose homeostasis
Versión del editorhttp://dx.doi.org/10.3389/fendo.2022.922825
URIhttp://hdl.handle.net/10261/282468
DOI10.3389/fendo.2022.922825
Identificadoresdoi: 10.3389/fendo.2022.922825
e-issn: 1664-2392
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