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Title: | Inhibitors of enzyme 06-alkylguanine-DNA-methyltransferase for cancer treatment |
Other Titles: | Inhibidores de la enzima 06-alquilguanina-ADN-metil-transferasa para el tratamiento del cáncer | Authors: | Ramírez Ortiz, Miguel Ángel; Morreale, Antonio; Gil Redondo, Rubén; Ruiz, Federico M. CSIC ORCID ; Fábrega Clavería, Carme; Bravo, Jerónimo CSIC ORCID | Issue Date: | 10-Dec-2009 | Citation: | ES 2330495 (A1) | Abstract: | The invention relates to the use of compounds derived from piperadinyl-methyl-tetrazole-quinolinone and derived from diphenyl-triazolo- pyrimidine as inhibitors of the reparative action of the DNA produced by enzyme O6-alkylguanine-DNA-methyltransferase, and to pharmaceutical compositions containing same, for the preparation of coadjuvant drugs for use in antitumour therapy using alkylating agents. La invención relaciona a la utilización de compuestos derivada de piperadinyl-metil-tetrazol-quinolinona y derivada de pirimidina del difenilo-triazolo como inhibidores de la acción reparativa de la DNA producida por la enzima O6-alkylguanine-DNA-methyltransferase, y a contener de las composiciones farmacéuticas mismo, para la preparación de los fármacos coadjuvant para el uso en terapia antitumour usando a agentes de alquilación. |
Description: | Fecha de solicitud: 10-12-2009.- Titular: Consejo Superior de Investigaciones Científicas (CSIC) | URI: | http://hdl.handle.net/10261/28125 |
Appears in Collections: | (CBM) Patentes (IBV) Patentes |
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ES2330495A1-1.pdf | 1,03 MB | Adobe PDF | ![]() View/Open |
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