Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/281146
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Condensation of the Drosophila nerve cord is oscillatory and depends on coordinated mechanical interactions |
Autor: | Karkali, Katerina CSIC ORCID ; Tiwari, Prabhat; Singh, Anand; Tlili, Sham; Jorba, Ignasi; Navajas, Daniel; Muñoz, José J.; Saunders, Timothy E.; Martín-Blanco, Enrique CSIC ORCID | Palabras clave: | Drosophila Morphogenesis Mechanics Central nervous system Ventral nerve cord Actomyosin Viscolelastic Model Neuron Glia |
Fecha de publicación: | 11-abr-2022 | Editor: | Elsevier | Citación: | Developmental Cell 57(7): 867-882.e5 (2022) | Resumen: | During development, organs reach precise shapes and sizes. Organ morphology is not always obtained through growth; a classic counterexample is the condensation of the nervous system during Drosophila embryogenesis. The mechanics underlying such condensation remain poorly understood. Here, we characterize the condensation of the embryonic ventral nerve cord (VNC) at both subcellular and tissue scales. This analysis reveals that condensation is not a unidirectional continuous process but instead occurs through oscillatory contractions. The VNC mechanical properties spatially and temporally vary, and forces along its longitudinal axis are spatially heterogeneous. We demonstrate that the process of VNC condensation is dependent on the coordinated mechanical activities of neurons and glia. These outcomes are consistent with a viscoelastic model of condensation, which incorporates time delays and effective frictional interactions. In summary, we have defined the progressive mechanics driving VNC condensation, providing insights into how a highly viscous tissue can autonomously change shape and size. | Versión del editor: | http://dx.doi.org/10.1016/j.devcel.2022.03.007 | URI: | http://hdl.handle.net/10261/281146 | DOI: | 10.1016/j.devcel.2022.03.007 | Identificadores: | doi: 10.1016/j.devcel.2022.03.007 issn: 1534-5807 e-issn: 1878-1551 |
Aparece en las colecciones: | (IBMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Condensation of the Drosophila_Karkali_Postprint_Art2022.pdf | 2,1 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
10
checked on 20-abr-2024
WEB OF SCIENCETM
Citations
10
checked on 29-feb-2024
Page view(s)
42
checked on 24-abr-2024
Download(s)
16
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.