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dc.contributor.authorSepúlveda, Borja-
dc.contributor.authorCarrascosa, Laura G.-
dc.contributor.authorRegatos, David-
dc.contributor.authorOtte, Marinus A.-
dc.contributor.authorFariña, David-
dc.contributor.authorLechuga, Laura M.-
dc.date.accessioned2010-09-24T13:14:29Z-
dc.date.available2010-09-24T13:14:29Z-
dc.date.issued2009-08-20-
dc.identifier.citationProceedings of SPIE 7397: 7397OY (2009)en_US
dc.identifier.issn0277-786X-
dc.identifier.urihttp://hdl.handle.net/10261/28001-
dc.description11 páginas, 9 figuras.-- Trabajo presentado en la conferencia "Biosensing II", 4-Agosto-2009, San Diego, CA, USA; Editores: Manijeh Razeghi, Hooman Mohseni.en_US
dc.description.abstractIn this work we summarize the main results obtained with the portable surface plasmon resonance (SPR) device developed in our group (commercialised by SENSIA, SL, Spain), highlighting its applicability for the real-time detection of extremely low concentrations of toxic pesticides in environmental water samples. In addition, we show applications in clinical diagnosis as, on the one hand, the real-time and label-free detection of DNA hybridization and single point mutations at the gene BRCA-1, related to the predisposition in women to develop an inherited breast cancer and, on the other hand, the analysis of protein biomarkers in biological samples (urine, serum) for early detection of diseases. Despite the large number of applications already proven, the SPR technology has two main drawbacks: (i) not enough sensitivity for some specific applications (where pM-fM or single-molecule detection are needed) (ii) low multiplexing capabilities. In order solve such drawbacks, we work in several alternative configurations as the Magneto-optical Surface Plasmon Resonance sensor (MOSPR) based on a combination of magnetooptical and ferromagnetic materials, to improve the SPR sensitivity, or the Localized Surface Plasmon Resonance (LSPR) based on nanostructures (nanoparticles, nanoholes,...), for higher multiplexing capabilities.en_US
dc.description.sponsorshipFinancial support from the M. Botin foundation is gratefully acknowledged.en_US
dc.format.extent1400321 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherThe International Society for Optics and Photonicsen_US
dc.rightsopenAccessen_US
dc.subjectSurface plasmon resonanceen_US
dc.subjectDNA detectionen_US
dc.subjectProtein biosensingen_US
dc.subjectMagneto-optic SPRen_US
dc.subjectLocalized surface plasmon resonanceen_US
dc.titleSurface plasmon resonance biosensors for highly sensitive detection in real samplesen_US
dc.typeartículoen_US
dc.identifier.doi10.1117/12.827062-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1117/12.827062en_US
dc.contributor.funderFundación Botín-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100006373es_ES
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