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Título: | Electrospun fibers of poly (lactic acid) containing bioactive glass and magnesium oxide nanoparticles for bone tissue regeneration |
Autor: | Canales, D. A.; Reyes, F.; Saavedra, M.; Peponi, Laura CSIC ORCID; Leonés, Adrián CSIC ORCID; Palza, H.; Boccaccini, A. R.; Grünewald, A.; Zapata, P. A. | Fecha de publicación: | 2022 | Editor: | Elsevier | Citación: | International Journal of Biological Macromolecules 210: 324-336 (2022) | Resumen: | Electrospun fibers of poly (lactic acid) (PLA) containing 10 and 20 wt% of bioactive glass (n-BG) and magnesium oxide (n-MgO) nanoparticles of ca. 27 and 23 nm respectively, were prepared toward to application in bone tissue engineering. The addition of both nanoparticles into the PLA will produce a synergic effect increasing its bioactivity and antimicrobial behavior. Neat PLA scaffold and the composites with MgO showed an average fiber diameter of 1.7 ± 0.6 μm, PLA/n-BG and PLA/n-BG/n-MgO fibers presented a significant diameter increase reaching values of ca. 3.1 ± 0.8 μm. Young's modulus of the electrospun scaffolds was affected by the direct presence of the particle and scaffold morphologies. All the composites having n-BG presented bioactivity through the precipitation of hydroxyapatite structures on the surface. Although n-MgO did not add bioactivity to the PLA fibers, they were able to render antimicrobial characteristics reducing the S. aureus viability around 30%, although an effect on E. coli strain was not observed. PLA/n-BG nanocomposites did not display any significant antimicrobial behavior. The different composites increased the alkaline phosphatase (ALP) expression as compared with pure PLA barely affecting the cell viability, meaning a good osteoblastic phenotype expression capacity, with PLA/n-BG presenting the highest osteoblastic expression. | Versión del editor: | http://dx.doi.org/10.1016/j.ijbiomac.2022.05.047 | URI: | http://hdl.handle.net/10261/277855 | DOI: | 10.1016/j.ijbiomac.2022.05.047 | Identificadores: | doi: 10.1016/j.ijbiomac.2022.05.047 issn: 1879-0003 |
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