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Título: | DNA-sequence and metal-ion specificity of the formation of *H-DNA |
Autor: | Bernués, Jordi CSIC ORCID ; Beltrán, Ramón; Casasnovas, José María CSIC ORCID ; Azorín, Ferran CSIC ORCID | Fecha de publicación: | 25-jul-1990 | Editor: | Oxford University Press | Citación: | Nucleic Acids Research 18(14): 4067-4073 (1990) | Resumen: | The homopyrimidine-homopurine sequence d(CT/GA)22 undergoes, in the presence of zinc ions, transition to an altered DNA conformation (*H-DNA) which is neither H-DNA nor B-DNA. *H-DNA is characterized by a peculiar chemical reactivity pattern in which most of the polypyrimidine strand is hyperreactive to osmium tetroxide and the central part of the polypurine strand is sensitive to diethylpyrocarbonate. Formation of *H-DNA is specific of metal-ion. *H-DNA is detected in the presence of Zn++, Cd++ and Mn++. The efficiency on promoting the transition is in the order of Zn++ greater than Cd++ much greater than Mn++. Formation of *H-DNA is also specific of nucleotide sequence. From all the different homopolymeric sequences tested only the d(CT/GA)22 sequence showed the zinc-induced transition to *H-DNA. These results suggest that stabilization of *H-DNA involves the formation of a specific complex between the metal-ion and the nucleotide sequence. The biological relevance of these results is discussed in view of the important role that zinc ions play on many nucleic acids processes. | Descripción: | 7 pages, 4 figures.-- PMID: 2377452 [PubMed].-- PMCID: PMC331161. | Versión del editor: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC331161 | URI: | http://hdl.handle.net/10261/27666 | ISSN: | 0305-1048 | E-ISSN: | 1362-4962 |
Aparece en las colecciones: | (IDAEA) Artículos |
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