Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/27623
Share/Export:
![]() ![]() |
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Title: | Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS |
Authors: | Nishijima, T.; Piriz, Joaquin CSIC ORCID; Duflot, Sylvie; Fernández García, Ana María CSIC ORCID ; Gaitán, Gema; Gómez-Pinedo, Ulises; García-Verdugo, José M.; Leroy, Félix; Soya, Hideaki; Núñez Molina, Ángel; Torres Alemán, Ignacio CSIC ORCID | Keywords: | Sysneuro Molneuro Signaling |
Issue Date: | 9-Sep-2010 | Publisher: | Elsevier | Citation: | Neuron 67(5): 834-846 (2010) | Abstract: | Upon entry into the central nervous system (CNS), serum insulin-like growth factor-1 (IGF-I) modulates neuronal growth, survival, and excitability. Yet mechanisms that trigger IGF-I entry across the blood-brain barrier remain unclear. We show that neuronal activity elicited by electrical, sensory, or behavioral stimulation increases IGF-I input in activated regions. Entrance of serum IGF-I is triggered by diffusible messengers (i.e., ATP, arachidonic acid derivatives) released during neurovascular coupling. These messengers stimulate matrix metalloproteinase-9, leading to cleavage of the IGF binding protein-3 (IGFBP-3). Cleavage of IGFBP-3 allows the passage of serum IGF-I into the CNS through an interaction with the endothelial transporter lipoprotein related receptor 1. Activity-dependent entrance of serum IGF-I into the CNS may help to explain disparate observations such as proneurogenic effects of epilepsy, rehabilitatory effects of neural stimulation, and modulatory effects of blood flow on brain activity. | Publisher version (URL): | http://dx.doi.org/10.1016/j.neuron.2010.08.007 | URI: | http://hdl.handle.net/10261/27623 | DOI: | 10.1016/j.neuron.2010.08.007 | ISSN: | 0896-6273 |
Appears in Collections: | (IC) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
NeuronCSICRepository.pdf | 601,5 kB | Adobe PDF | ![]() View/Open |
Review this work
SCOPUSTM
Citations
203
checked on May 8, 2022
WEB OF SCIENCETM
Citations
194
checked on May 13, 2022
Page view(s)
452
checked on May 16, 2022
Download(s)
518
checked on May 16, 2022
Google ScholarTM
Check
Altmetric
Dimensions
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.