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Título

Rosmarinic Acid-Loaded Polymeric Nanoparticles Prepared by Low-Energy Nano-Emulsion Templating: Formulation, Biophysical Characterization, and In Vitro Studies

AutorGarcía-Melero, Jessica; López-Mitjavila, Joan-Josep; García-Celma, M. J. CSIC ORCID; Rodríguez-Abreu, Carlos CSIC ORCID; Grijalvo, Santiago CSIC ORCID
Palabras claveProtein corona
PLGA
Antioxidant activity
Cellular uptake
Colloidal dispersions
Drug delivery
Nano-emulsions
Nanoparticles
Phytochemical
Fecha de publicación29-jun-2022
EditorMultidisciplinary Digital Publishing Institute
CitaciónMaterials 15 (13): 4572 (2022)
ResumenRosmarinic acid (RA), a caffeic acid derivative, has been loaded in polymeric nanoparticles made up of poly(lactic-co-glycolic acid) (PLGA) through a nano-emulsion templating process using the phase-inversion composition (PIC) method at room temperature. The obtained RA-loaded nanoparticles (NPs) were colloidally stable exhibiting average diameters in the range of 70-100 nm. RA was entrapped within the PLGA polymeric network with high encapsulation efficiencies and nanoparticles were able to release RA in a rate-controlled manner. A first-order equation model fitted our experimental data and confirmed the prevalence of diffusion mechanisms. Protein corona formation on the surface of NPs was assessed upon incubation with serum proteins. Protein adsorption induced an increase in the hydrodynamic diameter and a slight shift towards more negative surface charges of the NPs. The radical scavenging activity of RA-loaded NPs was also studied using the DPPH·assay and showed a dose-response relationship between the NPs concentration and DPPH inhibition. Finally, RA-loaded NPs did not affect the cellular proliferation of the human neuroblastoma SH-SY5Y cell line and promoted efficient cellular uptake. These results are promising for expanding the use of O/W nano-emulsions in biomedical applications.
Versión del editorhttps://doi.org/10.3390/ma15134572
URIhttp://hdl.handle.net/10261/275743
DOI10.3390/ma15134572
ISSN1996-1944
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