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Título

Biosensor based on peptide nucleic acid (PNA) molecules on gold surfaces, production method thereof and uses of same.

Otros títulosBiosensor basado en moléculas de ácido nucléico peptídico (PNA) sobre superficies de oro, procedimiento de obtención y sus aplicaciones.
Autor Martín-Gago, José A. ; Román García, Elisa Leonor ; Gómez-Navarro, Cristina; Briones, Carlos ; Mateo-Martí, Eva ; Parro-García, Víctor
Fecha de publicación 11-may-2006
Citación International Publication Number: WO 2006/048491 A1
ResumenThe invention relates to a biosensor which is obtained by immobilising peptide nucleic acid (PNA) molecules onto gold surfaces and to the uses thereof in the detection and characterisation of nucleic acid molecules (DNA or RNA) of biosanitary, environmental and dietary interest. The method of constructing said biosensors is based on the fact that PNA molecules can be immobilised in a controlled manner with one end thiolated onto monocrystalline or polycrystalline gold surfaces, such as to produce self-assembled monolayers (SAMs). The inventive biosensor can bind specifically to complementary DNA with a high sensitivity and a specificity that enables discrimination between DNA molecules which are differentiated in a single mutation or polymorphism and which do not require the pre-marking of the target molecule being analysed.
Descripción Filing Date: 2005-10-27.-- Priority Data ES P200402605 (2004-10-28)
URI http://hdl.handle.net/10261/2719
Aparece en las colecciones: (ICMM) Patentes
(CAB) Patentes
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