Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/269632
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | African Swine Fever Virus IAP Homologue Inhibits Caspase Activation and Promotes Cell Survival in Mammalian Cells |
Autor: | Nogal París, María Luisa; González de Buitrago, Gonzalo; Rodrı́guez, Clara ; Cubelos, Beatriz CSIC ORCID; Carrascosa, Ángel L.; Salas Falgueras, María Luisa CSIC ; Revilla Novella, Yolanda | Fecha de publicación: | 15-mar-2001 | Editor: | American Society for Microbiology | Citación: | Journal of Virology 75(6): 2535-2543 (2001) | Resumen: | African swine fever virus (ASFV) A224L is a member of the inhibitor of apoptosis protein (IAP) family. We have investigated the antiapoptotic function of the viral IAP both in stably transfected cells and in ASFV-infected cells. A224L was able to substantially inhibit caspase activity and cell death induced by treatment with tumor necrosis factor alpha and cycloheximide or staurosporine when overexpressed in Vero cells by gene transfection. We have also observed that ASFV infection induces caspase activation and apoptosis in Vero cells. Furthermore, using a deletion mutant of ASFV lacking the A224L gene, we have shown that the viral IAP modulates the proteolytic processing of the effector cell death protease caspase-3 and the apoptosis which are induced in the infected cells. Our findings indicate that A224L interacts with the proteolytic fragment of caspase-3 and inhibits the activity of this protease during ASFV infection. These observations could indicate a conserved mechanism of action for ASFV IAP and other IAP family members to suppress apoptosis. | Versión del editor: | https://doi.org/10.1128/JVI.75.6.2535-2543.2001 | URI: | http://hdl.handle.net/10261/269632 | DOI: | 10.1128/JVI.75.6.2535-2543.2001 | Identificadores: | issn: 0022-538X e-issn: 1098-5514 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
African_Swine_Fever_Nogal_PV_Art2001.pdf | 3,77 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
57
checked on 30-mar-2024
SCOPUSTM
Citations
110
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
104
checked on 26-feb-2024
Page view(s)
51
checked on 19-abr-2024
Download(s)
36
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.