English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/26815
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers

AutorFerreira, Rubén; Aviñó, Anna; Pérez-Tomás, Ricardo; Gargallo, Raimundo; Eritja Casadellà, Ramón
Fecha de publicación2010
EditorSage Publications
CitaciónJournal of Nucleic Acids 2010 (2010)
ResumenThe synthesis of oligomers containing two or three acridine units linked through 2-aminoethylglycine using solid-phase methodology is described. Subsequent studies on cell viability showed that these compounds are not cytotoxic. Binding to several DNA structures was studied by competitive dialysis, which showed a clear affinity for DNA sequences that form G-quadruplexes and parallel triplexes. The fluorescence spectra of acridine oligomers were affected strongly upon binding to DNA. These spectral changes were used to calculate the binding constants (K). Log K were found to be in the order of 4–6.
Descripción10 pages, 4 figures, 2 tables.
Versión del editorhttp://dx.doi.org/10.4061/2010/489060
URIhttp://hdl.handle.net/10261/26815
DOI10.4061/2010/489060
ISSN2090-021X (Online)
Aparece en las colecciones: (IQAC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Ferreira_Ruben_et_al.pdf864,34 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.