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Título: | Cell Therapy Based on Gingiva-Derived Mesenchymal Stem Cells Seeded in a Xenogeneic Collagen Matrix for Root Coverage of RT1 Gingival Lesions: An In Vivo Experimental Study |
Autor: | Sánchez, Nerea; Vignoletti, Fabio; Sanz Martín, Ignacio; Coca, Alejandro; Núñez, Javier; Maldonado, Estela; Sanz Esporrin, Javier; Hernando Pradíes, Irene; Santamaría, Silvia CSIC ORCID; Herrera, David; García-Sanz, José A. CSIC ORCID ; Sanz, Mariano | Palabras clave: | Cell therapies Mesenchymal stem cells Mesenchymal stromal cells Gingiva-derived stem cells Soft tissue regeneration Gingival recession Root coverage |
Fecha de publicación: | 17-mar-2022 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 23(6): 3248 (2022) | Resumen: | (1) Background: To investigate the effect of a xenogeneic collagen matrix (CMX) seeded with autologous gingiva-derived mesenchymal cells (GMSCs) when combined with a coronally advanced flap (CAF) in the treatment of localized gingival recession type 1 (RT1). (2) Methods: Dehiscence-type defects were created in seven dogs. GMSCs were isolated, transfected with a vector carrying green fluorescent protein (GFP) and expanded. Once chronified, the defects were randomly treated with (1) CAF plus the combination of CMX and GFP<sup>+</sup> GMSCs, (2) CAF plus CMX with autologous fibroblasts, (3) CAF plus CMX and (4) CAF alone. Histological and clinical outcomes at 2- and 6-week healing periods were analyzed and compared among groups. (3) Results: Histologically, the addition of autologous cells to the CMX resulted in reduced inflammation and a variable degree of new cementum/bone formation. CMX plus GMSCs resulted in greater mean recession reduction (1.42; SD = 1.88 mm) and percentage of teeth with recession reduction of ≥2 mm (57%) when compared to the other groups, although these differences were not statistically significant. (4) Conclusions: The histometric and clinical results indicated a positive trend favouring the combination of CMX and GMSCs with the CAF when compared to the groups without cells, although these differences were not statistically significant. | Versión del editor: | https://doi.org/10.3390/ijms23063248 | URI: | http://hdl.handle.net/10261/266129 | DOI: | 10.3390/ijms23063248 | ISSN: | 1661-6596 | E-ISSN: | 1422-0067 |
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