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Título: | Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening |
Autor: | Kohl, Yvonne; Biehl, Margit; Spring, Sarah; Hesler, Michelle; Ogourtsov, Vladimir; Todorovic, Miomir; Owen, Joshua; Elje, Elisabeth; Kopecka, Kristina; Moriones, Oscar Hernando CSIC ORCID; Bastús, Neus G. CSIC ORCID; Simon, Peter; Dubaj, Tibor; Rundén-Pran, Elise; Puntes, Víctor F. CSIC ORCID; William, Nicola; Briesen, Hagen von; Wagner, Sylvia; Kapur, Nikil; Mariussen, Espen; Nelson, Andrew; Gabelova, Alena; Dusinska, María; Velten, Thomas; Knoll, Thorsten | Fecha de publicación: | 18-ene-2021 | Editor: | John Wiley & Sons | Citación: | Small 17(15): 2006012 (2021) | Resumen: | Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal-free risk assessment of new chemicals and drugs. Microfluidic cell-based devices allow high-throughput screening and flexible automation while lowering costs and reagent consumption due to their miniaturization. There is a growing need for faster and animal-free approaches for drug development and safety assessment of chemicals (Registration, Evaluation, Authorisation and Restriction of Chemical Substances, REACH). The work presented describes a microfluidic platform for in vivo-like in vitro cell cultivation. It is equipped with a wafer-based silicon chip including integrated electrodes and a microcavity. A proof-of-concept using different relevant cell models shows its suitability for label-free assessment of cytotoxic effects. A miniaturized microscope within each module monitors cell morphology and proliferation. Electrodes integrated in the microfluidic channels allow the noninvasive monitoring of barrier integrity followed by a label-free assessment of cytotoxic effects. Each microfluidic cell cultivation module can be operated individually or be interconnected in a flexible way. The interconnection of the different modules aims at simulation of the whole-body exposure and response and can contribute to the replacement of animal testing in risk assessment studies in compliance with the 3Rs to replace, reduce, and refine animal experiments. | Versión del editor: | http://doi.org/10.1002/smll.202006012 | URI: | http://hdl.handle.net/10261/265395 | DOI: | 10.1002/smll.202006012 | Identificadores: | doi: 10.1002/smll.202006012 issn: 1613-6829 |
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Microfluidic_in_vitro_platform_nano_safety.pdf | 4,73 MB | Adobe PDF | Visualizar/Abrir |
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