Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/263291
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Magnetic Mesoporous Silica Nanorods Loaded with Ceria and Functionalized with Fluorophores for Multimodal Imaging |
Autor: | Grzelak, Jan Jacek; Gázquez, Jaume CSIC ORCID; Grayston, Alba; Teles, Mariana; Herranz, Fernando CSIC ORCID CVN; Roher, Nerea; Rosell, Anna; Roig Serra, Anna CSIC ORCID; Gich, Martí CSIC ORCID | Palabras clave: | Anisotropic nanoparticles Fluorescence imaging Magnetic resonance imaging Mesoporous silica rods Multimodal nanoparticles Superparamagnetic nanoparticles |
Fecha de publicación: | 25-feb-2022 | Editor: | American Chemical Society | Citación: | ACS Applied Nano Materials 5(2): 2113–2125 (2022) | Resumen: | Multifunctional magnetic nanocomposites based on mesoporous silica have a wide range of potential applications in catalysis, biomedicine, or sensing. Such particles combine responsiveness to external magnetic fields with other functionalities endowed by the agents loaded inside the pores or conjugated to the particle surface. Different applications might benefit from specific particle morphologies. In the case of biomedical applications, mesoporous silica nanospheres have been extensively studied while nanorods, with a more challenging preparation, have attracted much less attention despite the positive impact on the therapeutic performance shown by seminal studies. Here, we report on a sol-gel synthesis of mesoporous rodlike silica particles of two distinct lengths (1.4 and 0.9 μm) and aspect ratios (4.7 and 2.2) using Pluronic P123 as a structure-directing template and rendering ∼1 g of rods per batch. Iron oxide nanoparticles have been synthesized within the pores yielding maghemite (γ-Fe2O3) nanocrystals of elongated shape (∼7 nm × 5 nm) with a [110] preferential orientation along the rod axis and a superparamagnetic character. The performance of the rods as T2-weighted MRI contrast agents has also been confirmed. In a subsequent step, the mesoporous silica rods were loaded with a cerium compound and their surface was functionalized with fluorophores (fluorescamine and Cyanine5) emitting at λ = 525 and 730 nm, respectively, thus highlighting the possibility of multiple imaging modalities. The biocompatibility of the rods was evaluated in vitro in a zebrafish (Danio rerio) liver cell line (ZFL), with results showing that neither long nor short rods with magnetic particles caused cytotoxicity in ZFL cells for concentrations up to 50 μg/ml. We advocate that such nanocomposites can find applications in medical imaging and therapy, where the influence of shape on performance can be also assessed. | Versión del editor: | http://dx.doi.org/10.1021/acsanm.1c03837 | URI: | http://hdl.handle.net/10261/263291 | DOI: | 10.1021/acsanm.1c03837 | E-ISSN: | 2574-0970 |
Aparece en las colecciones: | (ICMAB) Artículos (IQM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Grzelak_ApplNanoMat_2022_editorial.pdf | Artículo principal | 10,3 MB | Adobe PDF | Visualizar/Abrir |
Grzelak_ApplNanoMat_2022_suppl_editorial.pdf | Información complementaria | 1,82 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
3
checked on 16-abr-2024
SCOPUSTM
Citations
10
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
9
checked on 23-feb-2024
Page view(s)
60
checked on 24-abr-2024
Download(s)
80
checked on 24-abr-2024