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Título: | Neuroprotective effect of terpenoids recovered from olive oil by-products |
Autor: | Suárez Montenegro, Zully J. CSIC ORCID; Álvarez-Rivera, Gerardo CSIC ORCID; Sánchez-Martínez, J. David CSIC ORCID; Gallego, Rocío CSIC ORCID; Valdés, Alberto CSIC ORCID; Bueno, Mónica CSIC ORCID ; Cifuentes, Alejandro CSIC ORCID ; Ibáñez, Elena CSIC ORCID | Palabras clave: | Olive oil by-products Neuroprotective effects Terpenes fractionation Alzheimer’s disease Adsorbent-assisted processes Supercritical CO2 extraction |
Fecha de publicación: | 2021 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Foods 10(7): 1507 (2021) | Resumen: | The neuroprotective potential of 32 natural extracts obtained from olive oil by-products was investigated. The online coupling of supercritical fluid extraction (SFE) and dynamic adsorption/desorption allowed the selective enrichment of olive leaves extracts in different terpenoids’ families. Seven commercial adsorbents based on silica gel, zeolite, aluminum oxide, and sea sand were used with SFE at three different extraction times to evaluate their selectivity towards different terpene families. Collected fractions were analyzed by gas chromatography coupled to quadrupole-time-of-flight mass spectrometry (GC-QTOF-MS) to quantify the recoveries of monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), and triterpenes (C30). A systematic analysis of the neuroprotective activity of the natural extracts was then carried out. Thus, a set of in vitro bioactivity assays including enzymatic (acetylcholinesterase (AChE), butyrylcholinesterase (BChE)), and anti-inflammatory (lipoxidase (LOX)), as well as antioxidant (ABTS), and reactive oxygen and nitrogen species (ROS and RNS, respectively) activity tests were applied to screen for the neuroprotective potential of these extracts. Statistical analysis showed that olive leaves adsorbates from SS exhibited the highest biological activity potential in terms of neuroprotective effect. Blood–brain barrier permeation and cytotoxicity in HK-2 cells and human THP-1 monocytes were studied for the selected olive leaves fraction corroborating its potential. | Descripción: | This article belongs to the Section Food Nutrition. | Versión del editor: | https://doi.org/10.3390/foods10071507 | URI: | http://hdl.handle.net/10261/263257 | DOI: | 10.3390/foods10071507 | E-ISSN: | 2304-8158 |
Aparece en las colecciones: | (CIAL) Artículos |
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