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Título: | Dissection of the regulatory elements of the complex expression pattern of puckered, a dual-specificity jnk phosphatase |
Autor: | Karkali, Katerina CSIC ORCID ; Martín-Blanco, Enrique CSIC ORCID | Palabras clave: | JNK Drosophila Dual specificity phosphatase Gene expression |
Fecha de publicación: | 2021 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 22(22): 12205 (2021) | Resumen: | For developmental processes, we know most of the gene networks controlling specific cell responses. We still have to determine how these networks cooperate and how signals become integrated. The JNK pathway is one of the key elements modulating cellular responses during development. Yet, we still know little about how the core components of the pathway interact with additional regulators or how this network modulates cellular responses in the whole organism in homeostasis or during tissue morphogenesis. We have performed a promoter analysis, searching for potential regulatory sequences of puckered (puc) and identified different specific enhancers directing gene expression in different tissues and at different developmental times. Remarkably, some of these domains respond to the JNK activity, but not all. Altogether, these analyses show that puc expression regulation is very complex and that JNK activities participate in non-previously known processes during the development of Drosophila. | Descripción: | © 2021 by the authors. | Versión del editor: | http://dx.doi.org/10.3390/ijms222212205 | URI: | http://hdl.handle.net/10261/263209 | DOI: | 10.3390/ijms222212205 | ISSN: | 1661-6596 | E-ISSN: | 1422-0067 |
Aparece en las colecciones: | (IBMB) Artículos |
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Dissection of the Regulatory_Karkali_PV_Art2021.pdf | 4,87 MB | Adobe PDF | Visualizar/Abrir |
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