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Título: | p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1 |
Autor: | Santamans, Ayelén M.; Montalvo-Romeral, Valle; Mora, Alfonso; Lopez, Juan Antonio; Gonzalez-Romero, Francisco; Jimenez-Blasco, Daniel CSIC ORCID; Rodríguez, Elena; Pintor-Chocano, Aránzazu; Casanueva-Benítez, Cristina; Acín-Pérez, Rebeca; Leiva-Vega, Luis; Duran, Joan; Guinovart, Joan J.; Jiménez-Borreguero, Jesús; Enríquez, José Antonio; Villlalba-Orero, María; Bolaños, Juan P. CSIC ORCID; Aspichueta, Patricia; Vázquez, Jesús CSIC ORCID CVN; González-Terán, Bárbara; Sabio, Guadalupe CSIC ORCID | Fecha de publicación: | 10-nov-2021 | Editor: | Public Library of Science | Citación: | PLoS Biology 19(11): e3001447 (2021) | Resumen: | During the first weeks of postnatal heart development, cardiomyocytes undergo a major adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This metabolic change is contemporaneous to the up-regulation and activation of the p38γ and p38δ stress-activated protein kinases in the heart. We demonstrate that p38γ/δ contribute to the early postnatal cardiac metabolic switch through inhibitory phosphorylation of glycogen synthase 1 (GYS1) and glycogen metabolism inactivation. Premature induction of p38γ/δ activation in cardiomyocytes of newborn mice results in an early GYS1 phosphorylation and inhibition of cardiac glycogen production, triggering an early metabolic shift that induces a deficit in cardiomyocyte fuel supply, leading to whole-body metabolic deregulation and maladaptive cardiac pathogenesis. Notably, the adverse effects of forced premature cardiac p38γ/δ activation in neonate mice are prevented by maternal diet supplementation of fatty acids during pregnancy and lactation. These results suggest that diet interventions have a potential for treating human cardiac genetic diseases that affect heart metabolism. | Versión del editor: | http://dx.doi.org/10.1371/journal.pbio.3001447 | URI: | http://hdl.handle.net/10261/262713 | DOI: | 10.1371/journal.pbio.3001447 | Identificadores: | doi: 10.1371/journal.pbio.3001447 issn: 1544-9173 e-issn: 1545-7885 |
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