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Título: | Evaluation of an O2-substituted (1–3)-β-D-Glucan, produced by Pediococcus parvulus 2.6, in ex vivo models of Crohn’s disease |
Autor: | Notararigo, Sara CSIC ORCID; Varela, Encarnación; Ottal, Anna; Cristobo, Iván CSIC; Antolín, María; Guarner, Francisco; Prieto Orzanco, Alicia CSIC ORCID ; López García, Paloma CSIC ORCID | Palabras clave: | Bacterial exopolysaccharides O2-substituted-(1-3)-β-D-glucan Lactic acid bacteria Immunomodulation Crohn´s disease anti-inflammatory effect |
Fecha de publicación: | 5-feb-2021 | Editor: | Frontiers Media | Citación: | Frontiers in Microbiology 2: 621280 (2021) | Resumen: | 1,3-β-glucans are extracellular polysaccharides synthesized by microorganisms and plants, with therapeutic potential. Among them, the O2-substituted-(1–3)-β-D-glucan, synthesized by some lactic acid bacteria (LAB), has a prebiotic effect on probiotic strains, an immunomodulatory effect on monocyte-derived macrophages, and potentiates the ability of the producer strain to adhere to Caco-2 cells differentiated to enterocytes. In this work, the O2-substituted-(1–3)-β-D-glucan polymers produced by GTF glycoyltransferase in the natural host Pediococcus parvulus 2.6 and in the recombinant strain Lactococcus lactis NZ9000[pNGTF] were tested. Their immunomodulatory activity was investigated in an ex vivo model using human biopsies from patients affected by Crohn’s disease (CD). Both polymers had an anti-inflammatory effect including, a reduction of Interleukine 8 both at the level of its gene expression and its secreted levels. The overall data indicate that the O2-substituted-(1–3)-β-D-glucan have a potential role in ameliorating inflammation via the gut immune system cell modulation. | Descripción: | 13 p.-4 fig-3 tab. | Versión del editor: | https://doi.org/10.3389/fmicb.2021.621280 | URI: | http://hdl.handle.net/10261/260055 | DOI: | 10.3389/fmicb.2021.621280 | E-ISSN: | 1664-302X |
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