Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/25785
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dc.contributor.authorOrtiz, Jordi-
dc.contributor.authorFabrias, Francesc-
dc.date.accessioned2010-06-29T12:01:01Z-
dc.date.available2010-06-29T12:01:01Z-
dc.date.issued1992-04-
dc.identifier.citationBritish Journal of Pharmacology 105(4): 941–946 (1992)en_US
dc.identifier.issn0007-1188-
dc.identifier.urihttp://hdl.handle.net/10261/25785-
dc.description6 pages, 5 figures, 1 table.-- PMID: 1387022 [PubMed].-- PMCID: PMC1908726.en_US
dc.description.abstractThe concentration of 5-hydroxytryptamine (5-HT) in rat platelet-free plasma increased significantly 30 min after a single i.p. injection (10 mg kg-1) of each of six inhibitors of the high-affinity 5-HT uptake (fluvoxamine, fluoxetine, alaproclate, paroxetine, sertraline and clomipramine). The increases ranged from 226% to 776% of control values. In contrast, imipramine, desipramine and femoxetine had no significant effect. The increase elicited by paroxetine was dependent on the dose (1, 5 and 10 mg kg-1) and returned to control values after 4 h. That observed after clomipramine was also transient and paralleled the plasma concentration of the drug (Spearman-rank correlation r = 0.43).en_US
dc.description.abstractIn vivo, the rat pulmonary vascular endothelium removed trace amounts (8.8 nmol in a bolus) of intravenously injected [14C]-5-HT. Paroxetine pretreatment (10 mg kg-1, 30 min before-hand) reduced this uptake by 73%.en_US
dc.description.abstractRepeated fluoxetine treatments reduced rat whole blood 5-HT concentration (ca. -60% after daily 2 x 5 mg kg-1, i.p. during 14 days). However, plasma (extracellular) 5-HT was not increased.en_US
dc.description.abstractVarious repeated treatments with clomipramine (i.p. injections or osmotic minipumps, up to 30 mg kg-1 day-1), failed to decrease rat whole blood 5-HT concentrations. Platelet-free plasma 5-HT was also unchanged, even after treatments yielding plasma clomipramine levels 2.7 times higher than those that increased it acutely.en_US
dc.description.abstractThese results indicate that the extracellular pool of 5-HT in rat blood (measured in the platelet-free plasma) is physiologically under the control of high-affinity 5-HT uptake systems.en_US
dc.description.sponsorshipThis work was supported by the Fondo de Investigaciones Sanitarias (89/0387). Thanks are also given to the pharmaceutical companies for kindly supplying the drugs.en_US
dc.format.extent1310868 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherNational Institutes of Health (U.S.). PubMed Centralen_US
dc.rightsopenAccessen_US
dc.subject5-hydroxytryptamine uptakeen_US
dc.subjectAntidepressant drugsen_US
dc.subjectUptake inhibitorsen_US
dc.subjectEndothelial uptakeen_US
dc.subjectClomipramineen_US
dc.subjectFluoxetineen_US
dc.subjectImipramineen_US
dc.subjectParoxetineen_US
dc.subjectPlateletsen_US
dc.subjectPlasmaen_US
dc.titleEffects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetineen_US
dc.typeartículoen_US
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908726en_US
dc.identifier.e-issn1476-5381-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
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