Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/25785
Share/Export:
![]() |
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Title: | Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine |
Authors: | Ortiz, Jordi; Fabrias, Francesc | Keywords: | 5-hydroxytryptamine uptake Antidepressant drugs Uptake inhibitors Endothelial uptake Clomipramine Fluoxetine Imipramine Paroxetine Platelets Plasma |
Issue Date: | Apr-1992 | Publisher: | National Institutes of Health (U.S.). PubMed Central | Citation: | British Journal of Pharmacology 105(4): 941–946 (1992) | Abstract: | The concentration of 5-hydroxytryptamine (5-HT) in rat platelet-free plasma increased significantly 30 min after a single i.p. injection (10 mg kg-1) of each of six inhibitors of the high-affinity 5-HT uptake (fluvoxamine, fluoxetine, alaproclate, paroxetine, sertraline and clomipramine). The increases ranged from 226% to 776% of control values. In contrast, imipramine, desipramine and femoxetine had no significant effect. The increase elicited by paroxetine was dependent on the dose (1, 5 and 10 mg kg-1) and returned to control values after 4 h. That observed after clomipramine was also transient and paralleled the plasma concentration of the drug (Spearman-rank correlation r = 0.43). In vivo, the rat pulmonary vascular endothelium removed trace amounts (8.8 nmol in a bolus) of intravenously injected [14C]-5-HT. Paroxetine pretreatment (10 mg kg-1, 30 min before-hand) reduced this uptake by 73%. Repeated fluoxetine treatments reduced rat whole blood 5-HT concentration (ca. -60% after daily 2 x 5 mg kg-1, i.p. during 14 days). However, plasma (extracellular) 5-HT was not increased. Various repeated treatments with clomipramine (i.p. injections or osmotic minipumps, up to 30 mg kg-1 day-1), failed to decrease rat whole blood 5-HT concentrations. Platelet-free plasma 5-HT was also unchanged, even after treatments yielding plasma clomipramine levels 2.7 times higher than those that increased it acutely. These results indicate that the extracellular pool of 5-HT in rat blood (measured in the platelet-free plasma) is physiologically under the control of high-affinity 5-HT uptake systems. |
Description: | 6 pages, 5 figures, 1 table.-- PMID: 1387022 [PubMed].-- PMCID: PMC1908726. | Publisher version (URL): | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908726 | URI: | http://hdl.handle.net/10261/25785 | ISSN: | 0007-1188 | E-ISSN: | 1476-5381 |
Appears in Collections: | (IQAC) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Ortiz_Jordi_et_al.pdf | 1,28 MB | Adobe PDF | ![]() View/Open |
Review this work
Page view(s)
306
checked on May 21, 2022
Download(s)
234
checked on May 21, 2022
Google ScholarTM
Check
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.