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| Título: | Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm |
Autor: | Santofimia-Castaño, Patricia; Rizzuti, Bruno; Xia, Yi; Abian, Olga CSIC ORCID; Peng, Ling; Velázquez-Campoy, Adrián; Iovanna, Juan Lucio; Neira, José L. CSIC ORCID | Palabras clave: | Drug design NUPR1 Intrinsically disordered protein Molecular dynamics Protein-protein interactions Spectroscopy |
Fecha de publicación: | 16-may-2019 | Editor: | Taylor & Francis | Citación: | Molecular and Cellular Biology 6 (5): e1612678 (2019) | Resumen: | Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs, using it to repurpose drugs for treating pancreatic adenocarcinoma (PDAC). | Descripción: | 3 pags, 1 fig | Versión del editor: | https://doi.org/10.1080/23723556.2019.1612678 | URI: | http://hdl.handle.net/10261/257709 | DOI: | 10.1080/23723556.2019.1612678 | E-ISSN: | 2372-3556 |
| Aparece en las colecciones: | (IQF) Artículos |
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| intrinsically_disordered_proteins.pdf | artículo principal | 1,4 MB | Adobe PDF |  Visualizar/Abrir |
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