Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/257708
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo |
Autor: | Sánchez-Aguilera, Alberto CSIC ORCID; Wheeler, D.W.; Jurado-Parras, Teresa CSIC; Valero, Manuel CSIC ORCID; Nokia, M.S.; Cid Ledesma, Elena CSIC ORCID; Fernández-Lamo, Iván CSIC; Sutton, N.; García-Rincón, Daniel CSIC; Menéndez de la Prida, Liset CSIC ORCID | Fecha de publicación: | 2021 | Editor: | Public Library of Science | Citación: | PLoS Biology 19 (2021) | Resumen: | Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal–hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) and complemented the dataset with our own new data. By confronting the effect of brain state and recording methods, we highlight the equivalences and differences across conditions and offer a number of novel observations. We show how a heuristic approach based on oscillatory features of morphologically identified neurons can aid in classifying extracellular recordings of single cells and discuss future opportunities and challenges towards integrating single-cell phenotypes with circuit function. | Versión del editor: | http://dx.doi.org/10.1371/journal.pbio.3001213 | URI: | http://hdl.handle.net/10261/257708 | DOI: | 10.1371/journal.pbio.3001213 | Identificadores: | doi: 10.1371/journal.pbio.3001213 issn: 1545-7885 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
An update to Hippocampome.org.pdf | 4,2 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
14
checked on 12-abr-2024
SCOPUSTM
Citations
16
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
14
checked on 22-feb-2024
Page view(s)
38
checked on 19-abr-2024
Download(s)
39
checked on 19-abr-2024