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Inhibition of Sema-3A Promotes Cell Migration, Axonal Growth, and Retinal Ganglion Cell Survival

AuthorsNitzan, Anat; Corredor, Miriam CSIC ORCID; Galron, Ronit; Nahary, Limor; Safrin, Mary; Bruzel, Marina; Moure, Alejandra; Bonet, Roman CSIC ; Pérez, Yolanda CSIC ORCID; Bujons Vilàs, Jordi; Vallejo-Yague, Enriqueta; Sacks, Hagit; Burnet, Michael; Alfonso, Ignacio CSIC ORCID ; Messeguer Peypoch, Ángel CSIC ORCID; Benhar, Itai; Barzilai, Ari; Solomon, Arieh S
KeywordsSemaphorin 3A
Issue Date12-Aug-2021
PublisherAssociation for Research in Vision and Ophthalmology
CitationTranslational Vision Science & Technology 10 (16) 2021
AbstractSemaphorin 3A (Sema-3A) is a secreted protein that deflects axons from inappropriate regions and induces neuronal cell death. Intravitreal application of polyclonal antibodies against Sema-3A prevents loss of retinal ganglion cells ensuing from axotomy of optic nerves. This suggested a therapeutic approach for neuroprotection via inhibition of the Sema-3A pathway.
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