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Título: | Antibacterial Polymers Based on Poly(2-hydroxyethyl methacrylate) and Thiazolium Groups with Hydrolytically Labile Linkages Leading to Inactive and Low Cytotoxic Compounds |
Autor: | Cuervo-Rodríguez, Rocío; López-Fabal, Fátima; Muñoz-Bonilla, Alexandra CSIC ORCID; Fernández-García, Marta CSIC ORCID | Palabras clave: | Antibacterial polymers Resistant bacteria RAFT polymerization Degradable polymers PH-sensitive linkage |
Fecha de publicación: | 2021 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | MATERIALS 14: 7477 (2021) | Resumen: | Herein, we develop a well-defined antibacterial polymer based on poly(2-hydroxyethyl methacrylate) (PHEMA) and a derivative of vitamin B1, easily degradable into inactive and bio- compatible compounds. Hence, thiazole moiety was attached to HEMA monomer through a car- bonate pH-sensitive linkage and the resulting monomer was polymerized via reversible addition- fragmentation chain transfer (RAFT) polymerization. N-alkylation reaction of the thiazole groups leads to cationic polymer with thiazolium groups. This polymer exhibits excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with an MIC value of 78 μg mL−1, whereas its degradation product, thiazolium small molecule, was found to be inactive. Hemotoxicity studies confirm the negligible cytotoxicity of the degradation product in comparison with the original antibacterial polymer. The degradation of the polymer at physiological pH was found to be progres- sive and slow, thus the cationic polymer is expected to maintain its antibacterial characteristics at physiological conditions for a relative long period of time before its degradation. This degradation minimizes antimicrobial pollution in the environment and side effects in the body after eradicating bacterial infection. | Versión del editor: | http://dx.doi.org/10.3390/ma14237477 | URI: | http://hdl.handle.net/10261/257379 | DOI: | 10.3390/ma14237477 | Identificadores: | doi: 10.3390/ma14237477 issn: 1996-1944 |
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